Individual Variability in the Structural Connectivity Architecture of the Human Brain.

Abstract

The human brain exhibits a high degree of individual variability in both its structure and function, which underlies intersubject differences in cognition and behavior. It was previously shown that functional connectivity is more variable in the heteromodal association cortex but less variable in the unimodal cortices. Structural connectivity (SC) is the anatomical substrate of functional connectivity, but the spatial and temporal patterns of individual variability in SC (IVSC) remain largely unknown. In the present study, we discovered a detailed and robust chart of IVSC obtained by applying diffusion MRI and tractography techniques to 1,724 adults (770 males and 954 females) from multiple imaging datasets. Our results showed that the SC exhibited the highest and lowest variability in the limbic regions and the unimodal sensorimotor regions, respectively. With increased age, higher IVSC was observed across most brain regions. Moreover, the specific spatial distribution of IVSC is related to the cortical laminar differentiation and myelination content. Finally, we proposed a modified ridge regression model to predict individual cognition and generated idiographic brain mapping, which was significantly correlated with the spatial pattern of IVSC. Overall, our findings further contribute to the understanding of the mechanisms of individual variability in brain SC and link to the prediction of individual cognitive function in adult subjects.