Pimpinellin mitigates DSS-induced ulcerative colitis in mice by reducing inflammation and regulating gut microbiota.

IF 6.7 1区医学 Q1 CHEMISTRY, MEDICINAL

Phytomedicine Pub Date : 2024-12-05 DOI:10.1016/j.phymed.2024.156308

Bin Lv, Lu Hou, Haolong Zhang, Cuiting Hao, Zheyu Song

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Abstract

Background: Pimpinellin is a phenylpropanoid compound involved in various physiological and pathological processes in the body. The specific impact of pimpinellin on ulcerative colitis (UC) remains uncertain. Research on pimpinellin by using a dextran sulfate sodium (DSS)-induced UC model can lay the groundwork for future drug screening and various treatment approaches for UC.

Purpose and methods: This research focused on investigating the effects and mechanisms of pimpinellin on DSS-induced UC in mice.

Results: The findings indicated that pimpinellin mitigated DSS-induced shortening of the colon and intestinal barrier damage and notably lowered inflammatory cytokine levels. Mechanistic analysis revealed that pimpinellin boosted the protein expression of intestinal barrier proteins by inhibiting the MAPK/NF-κB signaling pathway. Additionally, pimpinellin enhanced the levels of beneficial gut probiotics (S24-7 and Lactobacillaceae) while reducing the presence of harmful bacteria (Enterobacteriaceae). Further studies indicated that administering 100 mg/kg pimpinellin could significantly alleviate UC by modulating the gut microbiota.

Conclusion: In summary, timely use of pimpinellin can alleviate DSS-induced UC by reducing inflammation, maintaining intestinal barrier integrity, and adjusting gut microbiota. This research broadens the potential pharmaceutical applications of pimpinellin.

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Pimpinellin 通过减轻炎症和调节肠道微生物群减轻了 DSS 诱导的小鼠溃疡性结肠炎。

背景：Pimpinellin 是一种苯丙类化合物，参与体内各种生理和病理过程。皮素对溃疡性结肠炎（UC）的具体影响仍不确定。通过使用葡聚糖硫酸钠（DSS）诱导的 UC 模型对 pimpinellin 进行研究，可为未来 UC 的药物筛选和各种治疗方法奠定基础：目的和方法：本研究主要探讨了pimpinellin对DSS诱导的小鼠UC的影响和机制：结果：研究结果表明，pimpinellin可减轻DSS诱导的结肠缩短和肠屏障损伤，并显著降低炎性细胞因子水平。机理分析表明，金霉素通过抑制MAPK/NF-κB信号通路，促进了肠屏障蛋白的表达。此外，皮炎平还能提高有益肠道益生菌（S24-7 和乳酸杆菌）的水平，同时减少有害细菌（肠杆菌科）的存在。进一步的研究表明，服用100毫克/千克的皮炎平可通过调节肠道微生物群显著缓解UC：总之，适时使用pimpinellin可通过减轻炎症、维持肠道屏障完整性和调整肠道微生物群来缓解DSS诱导的UC。这项研究拓宽了皮炎平的潜在药物应用领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytomedicine 医学-药学

CiteScore

10.30

自引率

5.10%

发文量

670

审稿时长

91 days

期刊介绍： Phytomedicine is a therapy-oriented journal that publishes innovative studies on the efficacy, safety, quality, and mechanisms of action of specified plant extracts, phytopharmaceuticals, and their isolated constituents. This includes clinical, pharmacological, pharmacokinetic, and toxicological studies of herbal medicinal products, preparations, and purified compounds with defined and consistent quality, ensuring reproducible pharmacological activity. Founded in 1994, Phytomedicine aims to focus and stimulate research in this field and establish internationally accepted scientific standards for pharmacological studies, proof of clinical efficacy, and safety of phytomedicines.