Aspergillus hiratsukae as a causative agent of endophthalmitis: A case report.

IF 1.5 4区 生物学 Q4 MYCOLOGY
Revista Iberoamericana De Micologia Pub Date : 2024-04-01 Epub Date: 2024-12-11 DOI:10.1016/j.riam.2024.10.001
Cristian Mateo León, Ángeles Sampere Martínez, Isabel Fabelo Hidalgo, Diego García Martínez de Artola
{"title":"Aspergillus hiratsukae as a causative agent of endophthalmitis: A case report.","authors":"Cristian Mateo León, Ángeles Sampere Martínez, Isabel Fabelo Hidalgo, Diego García Martínez de Artola","doi":"10.1016/j.riam.2024.10.001","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Aspergillus flavus and Aspergillus fumigatus are commonly involved in fungal endophthalmitis. However, other less pathogenic species of the genus are also causal agents of opportunistic infections. Aspergillus hiratsukae, a species within Aspergillus section Fumigati, is an uncommon fungus responsible for a few infectious cases worldwide.</p><p><strong>Case report: </strong>We present a case of post-surgical endophthalmitis in a man caused by A. hiratsukae after phacoemulsification surgery and intraocular lens implantation. The patient underwent an urgent vitrectomy in which infectious foci were observed. Due to adverse clinical evolution, evisceration was performed five days after admission. In the study of the intraoperative samples fungal growth was observed. Microscopic analysis showed conidial heads resembling Aspergillus species. The final identification of A. hiratsukae was achieved by amplifying and sequencing the ITS1-5.8S-ITS2 spacer region. Antifungal susceptibility testing was performed using the method described by EUCAST. The isolate exhibited sensitivity to azoles and polyenes.</p><p><strong>Conclusions: </strong>Due to the morphological similarity of the Aspergillus species, molecular techniques are essential for discriminating among them, as there are different antifungal susceptibility profiles within the same complex. Further studies to improve clinical surveillance, make an early diagnosis and start a targeted therapy are necessary.</p>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":" ","pages":"48-50"},"PeriodicalIF":1.5000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Iberoamericana De Micologia","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.riam.2024.10.001","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/11 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MYCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Aspergillus flavus and Aspergillus fumigatus are commonly involved in fungal endophthalmitis. However, other less pathogenic species of the genus are also causal agents of opportunistic infections. Aspergillus hiratsukae, a species within Aspergillus section Fumigati, is an uncommon fungus responsible for a few infectious cases worldwide.

Case report: We present a case of post-surgical endophthalmitis in a man caused by A. hiratsukae after phacoemulsification surgery and intraocular lens implantation. The patient underwent an urgent vitrectomy in which infectious foci were observed. Due to adverse clinical evolution, evisceration was performed five days after admission. In the study of the intraoperative samples fungal growth was observed. Microscopic analysis showed conidial heads resembling Aspergillus species. The final identification of A. hiratsukae was achieved by amplifying and sequencing the ITS1-5.8S-ITS2 spacer region. Antifungal susceptibility testing was performed using the method described by EUCAST. The isolate exhibited sensitivity to azoles and polyenes.

Conclusions: Due to the morphological similarity of the Aspergillus species, molecular techniques are essential for discriminating among them, as there are different antifungal susceptibility profiles within the same complex. Further studies to improve clinical surveillance, make an early diagnosis and start a targeted therapy are necessary.

作为眼内炎致病菌的平曲霉:病例报告。
背景:黄曲霉和烟曲霉通常与真菌性眼内炎有关。然而,其他致病性较低的属也是机会性感染的致病因子。平松曲霉是烟曲霉科的一种,是一种罕见的真菌,在世界范围内引起一些传染性病例。病例报告:我们报告一例在超声乳化手术和人工晶状体植入术后,由平突芽胞杆菌引起的术后眼内炎。患者接受了紧急玻璃体切除术,其中观察到感染灶。由于临床进展不良,在入院5天后进行了内脏切除。术中标本观察真菌生长情况。显微分析显示分生孢子头类似曲霉属。通过对ITS1-5.8S-ITS2间隔区进行扩增和测序,最终鉴定了平松麻属。采用EUCAST方法进行抗真菌药敏试验。该分离物对偶氮和多烯敏感。结论:由于曲霉种类的形态相似性,在同一复合体内存在不同的抗真菌药敏谱,因此分子技术是鉴别曲霉种类的必要手段。进一步研究以改善临床监测、早期诊断和开始靶向治疗是必要的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
1.90
自引率
0.00%
发文量
17
审稿时长
81 days
期刊介绍: Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信