Health implications of racial differences in serum growth differentiation factor levels among men with obesity.

IF 2.2 Q3 PHYSIOLOGY

Physiological Reports Pub Date : 2024-12-01 DOI:10.14814/phy2.70124

Siresha Bathina, Virginia Fuenmayor Lopez, Mia Prado, Elliot Ballato, Georgia Colleluori, Maryam Tetlay, Dennis Tan Villareal, Sanjay Mediwala, Rui Chen, Clifford Qualls, Reina Armamento-Villareal

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引用次数: 0

Abstract

Growth differentiation factor (GDF15) has been considered a biomarker and recently a hormonal driver for diseases in different populations. However, the role of GDF15 as a biomarker of health outcomes in obese men from different racial/ethnic background has not been evaluated. The objective of this study was to investigate the racial/ethnic differences on the relationship between GDF15 and markers of glucometabolic status, hormonal profile, body composition and bone mineral density (BMD) in obese men. One hundred ninety-three obese men from diverse racial/ethnic backgrounds were enrolled. BMD and body composition were measured by dual energy X-ray absorptiometry. Serum GDF15, osteocalcin, C-terminal telopeptide, sclerostin, adiponectin, leptin, estradiol, testosterone, follicle-stimulating hormone, luteinizing hormone, 25-hydroxyvitamin D, lipid profile, and hemoglobin A1C (A1C) were measured. Non-African Americans (NAA) had significantly higher GDF15 level than African Americans (AA). Level was also higher in patients with type 2 diabetes (T2DM). In both the groups GDF15 correlated with A1C and lean mass. However. GDF15 correlated with body fat, LDL total cholesterol and femoral neck BMD only in NAA and with appendicular lean mass only in AA. Ethnicity, total cholesterol and T2DM were found to be independent predictors of GDF15. We conclude that GDF15 may influence glucometabolic status, body composition and bone parameters which may affect cardiovascular risk and osteoporosis between races.

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肥胖男性血清生长分化因子水平的种族差异对健康的影响。

生长分化因子（GDF15）一直被认为是一种生物标志物，最近还被认为是不同人群疾病的荷尔蒙驱动因素。然而，GDF15在不同种族/民族背景的肥胖男性中作为健康结果生物标志物的作用尚未得到评估。本研究的目的是调查肥胖男性中 GDF15 与糖代谢状态、荷尔蒙特征、身体成分和骨矿物质密度（BMD）等指标之间的种族/民族差异。研究人员招募了 193 名来自不同种族/民族背景的肥胖男性。骨密度和身体成分通过双能 X 射线吸收测定法进行测量。此外，还测量了血清 GDF15、骨钙素、C 端端肽、硬骨素、脂肪连通素、瘦素、雌二醇、睾酮、卵泡刺激素、促黄体生成素、25-羟维生素 D、血脂概况和血红蛋白 A1C（A1C）。非非洲裔美国人（NAA）的 GDF15 水平明显高于非洲裔美国人（AA）。2 型糖尿病（T2DM）患者的 GDF15 水平也更高。在这两个群体中，GDF15 都与 A1C 和瘦体重相关。然而。GDF15 仅在 NAA 中与体脂、低密度脂蛋白总胆固醇和股骨颈 BMD 相关，而在 AA 中仅与附属瘦体重相关。种族、总胆固醇和 T2DM 是 GDF15 的独立预测因素。我们的结论是，GDF15 可能会影响糖代谢状态、身体组成和骨骼参数，从而影响不同种族之间的心血管风险和骨质疏松症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physiological Reports PHYSIOLOGY-

CiteScore

4.20

自引率

4.00%

发文量

374

审稿时长

9 weeks

期刊介绍： Physiological Reports is an online only, open access journal that will publish peer reviewed research across all areas of basic, translational, and clinical physiology and allied disciplines. Physiological Reports is a collaboration between The Physiological Society and the American Physiological Society, and is therefore in a unique position to serve the international physiology community through quick time to publication while upholding a quality standard of sound research that constitutes a useful contribution to the field.