An outbreak of influenza A(H1N1)pdm09 antigenic variants exhibiting cross-resistance to oseltamivir and peramivir in an elementary school in Japan, September 2024.

IF 9.9 2区医学 Q1 INFECTIOUS DISEASES

Eurosurveillance Pub Date : 2024-12-01 DOI:10.2807/1560-7917.ES.2024.29.50.2400786

Emi Takashita, Kohei Shimizu, Shuzo Usuku, Ryuichi Senda, Ichiro Okubo, Hiroko Morita, Shiho Nagata, Seiichiro Fujisaki, Hideka Miura, Noriko Kishida, Kazuya Nakamura, Masayuki Shirakura, Masataka Ichikawa, Yoko Matsuzaki, Shinji Watanabe, Yoshimasa Takahashi, Hideki Hasegawa

引用次数: 0

Abstract

An outbreak of influenza A(H1N1)pdm09 viruses exhibiting cross-resistance to oseltamivir and peramivir occurred in Yokohama, Japan, in September 2024. Among 24 students in a class, 11 were diagnosed with influenza or influenza-like illness, and viruses harbouring the NA H275Y and HA Q210H substitutions were isolated from four. Deep sequencing analysis confirmed the clonal spread of these mutants. Antigenic analysis revealed differences from the vaccine strain. Continued monitoring is crucial to assess the potential for further spread of these mutant viruses.

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2024年9月，日本一所小学爆发对奥司他韦和帕拉米韦交叉耐药的甲型H1N1流感pdm09抗原变异。

2024年9月，日本横滨爆发了对奥司他韦和帕拉米韦具有交叉耐药性的甲型H1N1流感pdm09病毒。在一个班的24名学生中，有11名被诊断患有流感或流感样疾病，从4名学生中分离出含有NA H275Y和HA Q210H取代的病毒。深度测序分析证实了这些突变体的克隆传播。抗原分析显示与疫苗株存在差异。持续监测对于评估这些突变病毒进一步传播的可能性至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eurosurveillance INFECTIOUS DISEASES-

CiteScore

32.70

自引率

2.10%

发文量

430

审稿时长

3-8 weeks

期刊介绍： Eurosurveillance is a European peer-reviewed journal focusing on the epidemiology, surveillance, prevention, and control of communicable diseases relevant to Europe.It is a weekly online journal, with 50 issues per year published on Thursdays. The journal includes short rapid communications, in-depth research articles, surveillance reports, reviews, and perspective papers. It excels in timely publication of authoritative papers on ongoing outbreaks or other public health events. Under special circumstances when current events need to be urgently communicated to readers for rapid public health action, e-alerts can be released outside of the regular publishing schedule. Additionally, topical compilations and special issues may be provided in PDF format.