Pain sensitization in fibromyalgia. Cross-sectional associations between quantitative sensory testing of pain sensitization and fibromyalgia disease burden

IF 3.5 2区医学 Q1 ANESTHESIOLOGY

European Journal of Pain Pub Date : 2024-12-13 DOI:10.1002/ejp.4771

Pernille Steen Pettersen, Trond Haugmark, Inger Jorid Berg, Hilde Berner Hammer, Tuhina Neogi, Heidi Zangi, Ida K. Haugen, Sella Aarrestad Provan

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引用次数: 0

Abstract

Background

Whether fibromyalgia burden is related to measures of sensitization, assessed by quantitative sensory testing (QST), is not clear. We examine the associations between sensitization and fibromyalgia disease burden as measured by the polysymptomatic sistress scale (PDS) and the fibromyalgia impact questionnaire (FIQ) (range 0–100).

Materials and Methods

Participants were recruited from referrals to a rheumatology outpatient clinic and the fibromyalgia diagnosis was verified by a rheumatologist. They completed the PDS and FIQ and underwent QST of pressure pain threshold (PPT) at five sites, temporal summation (TS), and conditioned pain modulation (CPM) estimated as post-stimuli/pre-stimuli PPT. The associations between QST and disease burden were analysed in linear regression models adjusted for age, sex, and body mass index.

Results

A total of 78 individuals with clinically verified fibromyalgia (90% women, mean age 40.9 years (SD 7.3)) were recruited. Overall mean PPT was associated with the FIQ total score (β-2.1, 95% CI-4.3, −0.0) and the function component (β-2.1, (−4.3, −0.0)). When examining the associations between PPT at individual sites and fibromyalgia disease severity, PPTs at the distal interphalangeal joint and tibialis anterior muscle were associated with both FIQ total score and the FIQ fatigue component. All associations were weak and insignificant after Bonferroni corrections.

Conclusion

In this cohort of individuals with fibromyalgia, sensitization was not significantly associated with self-reported disease burden. Our results point to the multifactorial nature of fibromyalgia disease severity.

Significance

In patients with fibromyalgia, commonly used measures of sensitization do not explain the symptom burden or the functional impact.

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纤维肌痛的痛觉敏感化。疼痛敏感性定量感觉测试与纤维肌痛疾病负担之间的横截面关联。

背景：纤维肌痛负担是否与定量感觉试验（QST）评估的致敏措施有关尚不清楚。我们通过多症状压力量表（PDS）和纤维肌痛影响问卷（FIQ）（范围0-100）来检测致敏与纤维肌痛疾病负担之间的关系。材料和方法：参与者从风湿病门诊门诊的转诊中招募，纤维肌痛的诊断由风湿病学家验证。他们完成了PDS和FIQ，并在五个部位进行了压力疼痛阈值（PPT）的QST，时间累积（TS）和条件疼痛调节（CPM），估计为刺激后/刺激前PPT。通过调整年龄、性别和体重指数的线性回归模型分析QST与疾病负担之间的关系。结果：共招募了78名临床证实的纤维肌痛患者（90%为女性，平均年龄40.9岁（SD 7.3））。总体平均PPT与FIQ总分（β-2.1, 95% CI-4.3, -0.0）和功能成分（β-2.1,(-4.3, -0.0)）相关。当检查单个部位的PPT与纤维肌痛疾病严重程度之间的关系时，远端指间关节和胫骨前肌的PPT与FIQ总分和FIQ疲劳成分相关。经Bonferroni校正后，所有关联都很弱且不显著。结论：在这组纤维肌痛患者中，致敏与自我报告的疾病负担无显著相关性。我们的结果指出纤维肌痛疾病严重程度的多因素性质。意义：在纤维肌痛患者中，常用的致敏措施不能解释症状负担或功能影响。

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来源期刊

European Journal of Pain 医学-临床神经学

CiteScore

7.50

自引率

5.60%

发文量

163

审稿时长

4-8 weeks

期刊介绍： European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered. Regular sections in the journal are as follows: • Editorials and Commentaries • Position Papers and Guidelines • Reviews • Original Articles • Letters • Bookshelf The journal particularly welcomes clinical trials, which are published on an occasional basis. Research articles are published under the following subject headings: • Neurobiology • Neurology • Experimental Pharmacology • Clinical Pharmacology • Psychology • Behavioural Therapy • Epidemiology • Cancer Pain • Acute Pain • Clinical Trials.