Working memory deficit in patients with focal epilepsy is associated with higher interictal theta connectivity.

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2024-12-05 DOI:10.1016/j.clinph.2024.11.019

Simge Aykan, Virginie Laguitton, Samuel Medina Villalon, Stanislas Lagarde, Julia Makhalova, Fabrice Bartolomei, Christian-George Bénar

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引用次数: 0

Abstract

Objective: Interictal cognitive disturbances are frequent in patients with focal epilepsies and the links with alteration of resting state brain oscillations are not well known. Changes in theta oscillations, may contribute to cognitive impairment. This study aimed to investigate whether changes in theta activity are related to cognitive disturbances.

Methods: Retrospective data of 23 patients with temporal/frontal lobe epilepsy were included. Theta connectivity, power and interictal spikes rate from five-minute interictal resting state stereoelectroencephalography datasets were computed. Cognitive performances were assessed by Wechsler Intelligence Scale (WAIS-IV) and Weschler Memory Scale (WMS-III). Linear regression was performed to evaluate effect of interictal activity and seizure related parameters on cognitive scores.

Results: WAIS-IV working memory score in patients with epilepsy showed negative correlation with frontotemporal theta connectivity (F(1,17) = 5,239, p = 0,036, R² = 0,200, β = -0,497). Moreover, theta connectivity was correlated with mesial temporal spike rate and theta power (F(2,17) = 10,967, p = 0,001, adj.R² = 0,540).

Conclusions: Patients with focal epilepsy often encounter compromised cognitive functions, particularly notable in the domain of working memory. This impairment might be attributed to physiological mechanisms involving increased theta connectivity within the frontotemporal regions and interictal spiking.

Significance: Our study highlights the relation between theta connectivity and working memory impairments in patients with focal epilepsy.

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.