{"title":"The structure-dynamics feedback mechanism governs the glassy dynamics in epithelial monolayers.","authors":"Satyam Pandey, Soumitra Kolya, Padmashree Devendran, Souvik Sadhukhan, Tamal Das, Saroj Kumar Nandi","doi":"10.1039/d4sm01059k","DOIUrl":null,"url":null,"abstract":"<p><p>The glass-like slow dynamics in confluent epithelial monolayers is crucial for wound healing, embryogenesis, cancer progression, <i>etc.</i> Experiments have indicated several unusual properties in these systems. Unlike ordinary glasses, the glassiness in cellular systems strongly correlates with their static properties and is sub-Arrhenius. These results imply that the slow dynamics in epithelial monolayers is either not glassy or the underlying mechanism is different from ordinary glasses. Combining the analytical mode-coupling theory (MCT), vertex model simulations, and cellular experiments, we show that the slow dynamics is glassy, though the mechanism differs from ordinary glasses. The structure-dynamics feedback mechanism of MCT, and not the barrier-crossing mechanism, dominates the glassy dynamics, where the relaxation time diverges as a power law with a universal exponent 3/2 and naturally explains the sub-Arrhenius relaxation. Our results suggest the possibility of describing various complex biological processes like cell division and apoptosis <i>via</i> the static properties of the systems, such as average cell shape or shape variability.</p>","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Soft Matter","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4sm01059k","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
The glass-like slow dynamics in confluent epithelial monolayers is crucial for wound healing, embryogenesis, cancer progression, etc. Experiments have indicated several unusual properties in these systems. Unlike ordinary glasses, the glassiness in cellular systems strongly correlates with their static properties and is sub-Arrhenius. These results imply that the slow dynamics in epithelial monolayers is either not glassy or the underlying mechanism is different from ordinary glasses. Combining the analytical mode-coupling theory (MCT), vertex model simulations, and cellular experiments, we show that the slow dynamics is glassy, though the mechanism differs from ordinary glasses. The structure-dynamics feedback mechanism of MCT, and not the barrier-crossing mechanism, dominates the glassy dynamics, where the relaxation time diverges as a power law with a universal exponent 3/2 and naturally explains the sub-Arrhenius relaxation. Our results suggest the possibility of describing various complex biological processes like cell division and apoptosis via the static properties of the systems, such as average cell shape or shape variability.
期刊介绍:
Soft Matter is an international journal published by the Royal Society of Chemistry using Engineering-Materials Science: A Synthesis as its research focus. It publishes original research articles, review articles, and synthesis articles related to this field, reporting the latest discoveries in the relevant theoretical, practical, and applied disciplines in a timely manner, and aims to promote the rapid exchange of scientific information in this subject area. The journal is an open access journal. The journal is an open access journal and has not been placed on the alert list in the last three years.