The Intrinsic Fluorescence of Peptide Self-Assemblies Across pH Levels

IF 16.1 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Xiaoyu Wang, Yuqing Yang, Haokun Yang, Hao Dong
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引用次数: 0

Abstract

The regulation of solution pH on the structural and optical properties of peptide self-assemblies remains a critical yet unresolved issue in peptide research. This study investigates the heptapeptide Ac-IHIHIQI-NH2 and its intrinsic fluorescence across a range of pH levels, demonstrating that variations in pH lead to significant changes in the morphology of the self-assembled structures. While the position of the fluorescence emission remains constant—due to the stability provided by the hydrogen bonding network of the peptide backbone—the intensity of the fluorescence exhibits a direct correlation with the degree of self-assembly. This finding underscores a dynamic relationship between structural morphology and optical properties. Notably, the ability of the peptide to self-assemble under diverse pH conditions is a novel observation that contrasts with previously reported literature. By employing a computationally driven approach, complemented by rigorous experimental validation, this work establishes a new paradigm for studying complex interacting systems such as peptide self-assembly. Our findings enhance the understanding of how environmental factors influence peptide behavior and pave the way for the design of innovative peptide-based materials with tunable optical characteristics, with potential applications in bioluminescent probes and diagnostic tools for neurodegenerative diseases.
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来源期刊
CiteScore
26.60
自引率
6.60%
发文量
3549
审稿时长
1.5 months
期刊介绍: Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.
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