Kirigami Design Smart Contact Lens for Highly Sensitive Eyelid Pressure Measurement

IF 8.2 1区化学 Q1 CHEMISTRY, ANALYTICAL

ACS Sensors Pub Date : 2024-12-12 DOI:10.1021/acssensors.4c02361

Wen Chen, Songhao Chen, Xiaoyu Zhao, Lan Yang, Yunbiao Zhao, Ruihua Wei, Jinfang Wu

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Abstract

Eyelid pressure is a crucial biomechanical parameter for ocular health and refractive status, yet measuring it poses challenges related to flexibility, sensitivity, and regional specificity. This study introduces a novel smart contact lens that incorporates kirigami designs and an iontronic capacitive sensing array to enhance flexibility and conformability. The unique structural composition of this device allows for precise and simultaneous monitoring of eyelid pressure in multiple regions with a high sensitivity and seamlessly fit across corneal curvatures. The efficacy of the sensor has been thoroughly confirmed through comprehensive evaluations in rabbits and porcine eyes, demonstrating improved conformity and sensitivity compared to conventional single-point sensors. Assessments have been conducted in various conditions, including under anesthesia and in awake states, as well as the deliberate alteration of intraocular pressure fluctuations, all affirming the exceptional accuracy in detecting eyelid pressure. We envision that the smart contact lens has the potential to revolutionize diagnosis and management of eyelid-related ocular diseases.

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Kirigami设计的高敏感眼睑压力测量智能隐形眼镜

眼睑压是眼健康和屈光状态的重要生物力学参数，但测量它存在与灵活性、敏感性和区域特异性相关的挑战。本研究介绍了一种新型的智能隐形眼镜，它结合了kirigami设计和离子电容传感阵列，以提高灵活性和一致性。该设备独特的结构组成允许精确和同时监测多个区域的眼睑压力，具有高灵敏度，并无缝地适应角膜曲率。该传感器的有效性已通过兔眼和猪眼的综合评估得到彻底证实，与传统的单点传感器相比，其一致性和灵敏度都有所提高。在各种情况下进行了评估，包括麻醉和清醒状态，以及故意改变眼压波动，所有这些都证实了检测眼睑压的异常准确性。我们设想，智能隐形眼镜有可能彻底改变与眼睑有关的眼部疾病的诊断和管理。

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来源期刊

ACS Sensors Chemical Engineering-Bioengineering

CiteScore

14.50

自引率

3.40%

发文量

372

期刊介绍： ACS Sensors is a peer-reviewed research journal that focuses on the dissemination of new and original knowledge in the field of sensor science, particularly those that selectively sense chemical or biological species or processes. The journal covers a broad range of topics, including but not limited to biosensors, chemical sensors, gas sensors, intracellular sensors, single molecule sensors, cell chips, and microfluidic devices. It aims to publish articles that address conceptual advances in sensing technology applicable to various types of analytes or application papers that report on the use of existing sensing concepts in new ways or for new analytes.