Intermittent fasting triggers interorgan communication to suppress hair follicle regeneration

IF 45.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2024-12-13 DOI:10.1016/j.cell.2024.11.004

Han Chen, Chao Liu, Shiyao Cui, Yingqian Xia, Ke Zhang, Hanxiao Cheng, Jingyu Peng, Xiaoling Yu, Luyang Li, Hualin Yu, Jufang Zhang, Ju-Sheng Zheng, Bing Zhang

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Abstract

Intermittent fasting has gained global popularity for its potential health benefits, although its impact on somatic stem cells and tissue biology remains elusive. Here, we report that commonly used intermittent fasting regimens inhibit hair follicle regeneration by selectively inducing apoptosis in activated hair follicle stem cells (HFSCs). This effect is independent of calorie reduction, circadian rhythm alterations, or the mTORC1 cellular nutrient-sensing mechanism. Instead, fasting activates crosstalk between adrenal glands and dermal adipocytes in the skin, triggering the rapid release of free fatty acids into the niche, which in turn disrupts the normal metabolism of HFSCs and elevates their cellular reactive oxygen species levels, causing oxidative damage and apoptosis. A randomized clinical trial (NCT05800730) indicates that intermittent fasting inhibits human hair growth. Our study uncovers an inhibitory effect of intermittent fasting on tissue regeneration and identifies interorgan communication that eliminates activated HFSCs and halts tissue regeneration during periods of unstable nutrient supply.

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间歇性禁食因其潜在的健康益处而在全球广受欢迎，但它对体细胞干细胞和组织生物学的影响仍然难以捉摸。在此，我们报告了常用的间歇性禁食方案通过选择性诱导活化的毛囊干细胞（HFSCs）凋亡来抑制毛囊再生。这种效应与热量减少、昼夜节律改变或mTORC1细胞营养传感机制无关。相反，禁食会激活皮肤中肾上腺和真皮脂肪细胞之间的串联，引发游离脂肪酸快速释放到皮层中，进而扰乱毛囊干细胞的正常新陈代谢，提高其细胞活性氧水平，造成氧化损伤和细胞凋亡。一项随机临床试验（NCT05800730）表明，间歇性禁食会抑制人类毛发生长。我们的研究发现了间歇性禁食对组织再生的抑制作用，并确定了在营养供应不稳定期间消除活化的高频间充质干细胞和停止组织再生的器官间通讯。

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.

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