Jia-Yuan Yin, Meng Lai, Xiao-Ying Yu, Ding-Ding Su, Xing-Yao Xiong, Yan-Lin Li
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引用次数: 0
Abstract
Taxus L., an important ornamental, economic, and medicinal plant, is renowned for producing paclitaxel (Taxol®), a potent chemotherapeutic agent. The biosynthesis of paclitaxel involves intricate biosynthetic pathways, spanning multiple enzymatic steps. Despite advances, challenges remain in optimizing production methods. Microorganisms, particularly endophytic fungi, show potential in producing paclitaxel, though with limitations in yield and stability. The suspension culture of Taxus cells is a promising alternative, offering sustainable production, yet it requires further genetic and environmental optimization. Recent advancements in synthetic biology have enabled partial reconstitution of paclitaxel pathways in microbial and plant chassis. However, achieving complete biosynthesis remains an ongoing challenge. This review consolidates recent progress in paclitaxel biosynthesis, highlighting current limitations and future prospects for industrial-scale production.
期刊介绍:
Horticulture Research, an open access journal affiliated with Nanjing Agricultural University, has achieved the prestigious ranking of number one in the Horticulture category of the Journal Citation Reports ™ from Clarivate, 2022. As a leading publication in the field, the journal is dedicated to disseminating original research articles, comprehensive reviews, insightful perspectives, thought-provoking comments, and valuable correspondence articles and letters to the editor. Its scope encompasses all vital aspects of horticultural plants and disciplines, such as biotechnology, breeding, cellular and molecular biology, evolution, genetics, inter-species interactions, physiology, and the origination and domestication of crops.