Chorioamnionitis and earlier gestational age are associated with neonatal hypercalcemia after maternal magnesium sulfate therapy: A case-control study.

IF 2.3 4区 医学 Q2 PEDIATRICS
Takahiro Tominaga, Yoshiko Seki, Sayu Omori-Shimano, Kazushige Ikeda, Yuki Shiko, Hiromichi Hamada, Midori Awazu
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引用次数: 0

Abstract

Background: Magnesium sulfate (MgSO4) is a tocolytic agent used to treat gestational hypertension and to prevent preterm labor. Neonatal hypocalcemia is a well-known side effect of maternal MgSO4 use. Cases of neonatal hypercalcemia after maternal MgSO4 have been reported. Little is known about neonatal hypercalcemia following maternal MgSO4 therapy. We investigated the frequency and risk factors of neonatal hypercalcemia in this setting.

Methods: This case-control study investigated serum calcium in neonates born within 24 h after maternal MgSO4 administration. We reviewed the electronic medical records of Saitama City Hospital for pregnant women who were treated with MgSO4 between January 2016 and December 2021. There were 504 pregnant women that were treated with MgSO4. We enrolled 257 neonates. Hypercalcemia was defined as serum albumin-corrected calcium greater than 2.74 mmol/L (11 mg/dL). We collected the perinatal information from the mothers and neonates.

Results: Twenty-one neonates (8%) had hypercalcemia at birth (H group). Umbilical arterial ionized calcium, neonatal plasma ionized calcium, and total serum calcium were significantly higher in H group than in N group. Neonatal serum albumin, on the other hand, was lower in H group than in N group. Neonates in H group were born earlier (28.4 ± 3.1 vs. 32.4 ± 3.1 wk, p < 0.001) and more likely to be born to mothers with pathological chorioamnionitis (91.0% vs. 12.7%, p < 0.001) than neonates who were normocalcemic (N group). Serum alkaline phosphatase was lower in H group (661 ± 276 vs. 816 ± 265 U/L, p = 0.01). Multivariate analysis showed that earlier gestational age and chorioamnionitis were significant risk factors.

Conclusion: Hypercalcemia after maternal MgSO4 was seen in 8% of neonates. Maternal chorioamnionitis and earlier gestational age were associated with this condition.

绒毛膜羊膜炎和早期胎龄与产妇硫酸镁治疗后新生儿高钙血症相关:一项病例对照研究
背景:硫酸镁(MgSO4)是一种用于治疗妊娠期高血压和预防早产的抗胎药。新生儿低钙血症是母亲使用硫酸镁的一个众所周知的副作用。新生儿高钙血症的病例报告后,产妇MgSO4。对产妇MgSO4治疗后新生儿高钙血症的了解甚少。我们调查了这种情况下新生儿高钙血症的发生频率和危险因素。方法:采用病例对照研究方法,对母亲给药后24 h内出生的新生儿血清钙进行测定。我们查阅了埼玉市医院2016年1月至2021年12月期间接受MgSO4治疗的孕妇的电子病历。504名孕妇接受MgSO4治疗。我们招募了257名新生儿。高钙血症定义为血清白蛋白校正钙大于2.74 mmol/L (11 mg/dL)。我们收集了母亲和新生儿的围产期信息。结果:H组新生儿出生时高钙血症21例(8%)。H组脐动脉离子钙、新生儿血浆离子钙、血清总钙显著高于N组。H组新生儿血清白蛋白明显低于N组。H组新生儿出生早(28.4±3.1 vs. 32.4±3.1)周,p结论:产妇MgSO4后新生儿出现高钙血症的比例为8%。母体绒毛膜羊膜炎和胎龄较早与此病有关。
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来源期刊
CiteScore
3.10
自引率
0.00%
发文量
170
审稿时长
48 days
期刊介绍: Pediatrics and Neonatology is the official peer-reviewed publication of the Taiwan Pediatric Association and The Society of Neonatology ROC, and is indexed in EMBASE and SCOPUS. Articles on clinical and laboratory research in pediatrics and related fields are eligible for consideration.
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