Association between serum copeptin levels and non-obese normoglycemic polycystic ovary syndrome: A case control study.

IF 1 Q4 OBSTETRICS & GYNECOLOGY
Engin Yıldırım, Ümit Görkem
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Abstract

Objective: Copeptin is a glycopeptide that increases under stress and is present in polycystic ovary syndrome (PCOS) patients with metabolic system disorders. We examined the relationship between copeptin and reproductive function in patients with normoglycemic PCOS with anovulatory cycles and normal weight.

Materials and methods: Women with unexplained infertility (n=52) and women with PCOS (n=57) were included in the study. PCOS was determined using the Rotterdam criteria. Biochemical tests including estradiol, follicle-stimulating hormone, luteinizing hormone, anti-Müllerian hormone (AMH), insulin, and copeptin were performed. Serum copeptin concentrations were measured using enzyme immunoassay.

Results: There were no significant differences in demographic data, insulin levels, and insulin resistance between the PCOS and healthy volunteers. Copeptin levels were lower in the PCOS group (p<0.001). A significant negative correlation was observed between AMH and copeptin in the control group (r=-0.402, p= 0.013). In the PCOS group, a negative correlation was observed between antral follicle count and copeptin, as well as between AMH and copeptin (r=-0.544, p<0.01). Receiver operating characteristic (ROC) curve analysis was performed to determine the predictive value of copeptin levels. The estimated areas under the ROC curves for serum concentration were found to be statistically significant (p<0.001) with a cut-off value of 2.78 (95% confidence interval 0.701-0.896), sensitivity of 0.87, and specificity of 0.70.

Conclusion: This study showed that copeptin levels are lower in patients with PCOS in the absence of insulin resistance and obesity than in healthy volunteers, and there is a negative correlation between copeptin and reproductive markers.

血清copeptin水平与非肥胖型血糖正常型多囊卵巢综合征的关系:一项病例对照研究。
目的:Copeptin是一种糖肽,在应激下增加,存在于多囊卵巢综合征(PCOS)代谢系统紊乱患者中。我们研究了正常血糖、无排卵周期、体重正常的PCOS患者的copeptin与生殖功能的关系。材料与方法:纳入原因不明性不孕症患者(n=52)和PCOS患者(n=57)。多囊卵巢综合征是根据鹿特丹标准确定的。生化试验包括雌二醇、促卵泡激素、黄体生成素、抗勒氏激素(AMH)、胰岛素、copeptin。采用酶免疫分析法测定血清copeptin浓度。结果:多囊卵巢综合征患者与健康志愿者在人口学数据、胰岛素水平和胰岛素抵抗方面无显著差异。结论:本研究显示,无胰岛素抵抗和肥胖的PCOS患者Copeptin水平低于健康志愿者,Copeptin与生殖指标呈负相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
2.10
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