Archetypal Analysis Reveals Consistent Visual Field Patterns for Stimulus Sizes III and V in Glaucoma and NAION.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Translational Vision Science & Technology Pub Date : 2024-12-02 DOI:10.1167/tvst.13.12.15

David Szanto, Michael Wall, Luke X Chong, Brian Woods, Tobias Elze, Jui-Kai Wang, Mona Garvin, Randy Kardon, Mark J Kupersmith

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引用次数: 0

Abstract

Purpose: Disorders of the anterior optic nerve cause quantifiable patterns, or archetypes (AT), in visual fields (VFs) obtained using standardized automated perimetry using stimulus size III (size III). VFs with stimulus size V (size V) can reduce retest variability in eyes with moderate to severe loss. We postulated that VF testing using both stimuli would show similar ATs in eyes with glaucoma and nonarteritic anterior ischemic optic neuropathy (NAION).

Methods: We used 1969 same-day pairs of 24-2 size III and size V VFs from two datasets. QRK207 is the largest NAION study to date, and the VIPII study measured same-day VFs across many stimulus sizes. We censored raw sensitivities of less than 21 dB for size III and 24 dB for size V and age-standardized to total deviations, before archetypal analysis (AA). We compared the ATs between the two stimuli and the combined data.

Results: Using 14 ATs for both glaucoma and NAION, AA captured similar patterns between the two stimuli in both diseases with 87% of AT pairings having a cosine similarity of 0.8 or greater. The combined ATs retained the patterns in the separate stimuli VFs.

Conclusions: AA shows that size V VFs provide quantifiable patterns of loss similar to size III. This aids in comparing stimulus sizes for monitoring VF patterns in disease progression.

Translational relevance: AA shows similar quantifiable patterns of VF loss with size III or size V, supporting the use of size V to monitor eyes with moderate to severe VF loss.

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来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.