Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms

IF 3.9 3区生物学 Q2 MICROBIOLOGY

MicrobiologyOpen Pub Date : 2024-12-12 DOI:10.1002/mbo3.70011

Gilda Padalino, Katrina Duggan, Luis A. J. Mur, Jean-Yves Maillard, Andrea Brancale, Karl F. Hoffmann

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Abstract

Antimicrobial resistance remains a global issue, hindering the control of bacterial infections. This study examined the antimicrobial properties of 2,3-N,N-diphenyl quinoxaline derivatives against Gram-positive, Gram-negative, and Mycobacterium species. Two quinoxaline derivatives (compounds 25 and 31) exhibited significant activity against most strains of Staphylococcus aureus, Enterococcus faecium, and Enterococcus faecalis tested, with MIC values ranging from 0.25 to 1 mg/L. These compounds also showed effective antibacterial activity against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant E. faecium/E. faecalis (VRE) strains. They demonstrated comparable or superior activity to four current antibiotics (vancomycin, teicoplanin, daptomycin, and linezolid) against a wide range of clinically relevant isolates. Additionally, they were more effective in preventing S. aureus and E. faecalis biofilm formation compared to several other antibiotics. In summary, these two quinoxaline derivatives have potential as new antibacterial agents.

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含有2,3-双（苯胺）喹啉的化合物对耐甲氧西林金黄色葡萄球菌、粪肠球菌及其生物膜具有活性。

抗微生物药物耐药性仍然是一个全球性问题，阻碍了对细菌感染的控制。本研究检测了2,3- n， n -二苯基喹啉衍生物对革兰氏阳性、革兰氏阴性和分枝杆菌的抗菌性能。两种喹诺啉衍生物（化合物25和31）对大多数金黄色葡萄球菌、屎肠球菌和粪肠球菌具有显著的活性，其MIC值在0.25至1 mg/L之间。这些化合物对耐甲氧西林金黄色葡萄球菌（MRSA）和耐万古霉素大肠杆菌（E. faecium/E.）也显示出有效的抗菌活性。粪球菌（VRE）菌株。它们对广泛的临床相关分离株表现出与目前使用的四种抗生素（万古霉素、替柯普兰、达托霉素和利奈唑胺）相当或更好的活性。此外，与其他几种抗生素相比，它们在预防金黄色葡萄球菌和粪肠球菌生物膜形成方面更有效。综上所述，这两种喹诺啉衍生物具有作为新型抗菌剂的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

MicrobiologyOpen MICROBIOLOGY-

CiteScore

8.00

自引率

0.00%

发文量

审稿时长

20 weeks

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