Accurate Intramyocardial Hemorrhage Assessment with Fast, Free-running, Cardiac Quantitative Susceptibility Mapping.
IF 3.8
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Yuheng Huang, Xingmin Guan, Xinheng Zhang, Ghazal Yoosefian, Hao Ho, Li-Ting Huang, Hsin-Yao Lin, Gregory Anthony, Hsu-Lei Lee, Xiaoming Bi, Fei Han, Shing Fai Chan, Keyur P Vora, Behzad Sharif, Dhirendra P Singh, Khalid Youssef, Debiao Li, Hui Han, Anthony G Christodoulou, Rohan Dharmakumar, Hsin-Jung Yang
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引用次数: 0
Abstract
Purpose To evaluate the performance of a high-dynamic-range quantitative susceptibility mapping (HDR-QSM) cardiac MRI technique to detect intramyocardial hemorrhage (IMH) and quantify iron content using phantom and canine models. Materials and Methods A free-running whole-heart HDR-QSM technique for IMH assessment was developed and evaluated in calibrated iron phantoms and 14 IMH female canine models. IMH detection and iron content quantification performance of this technique was compared with the conventional iron imaging approaches, R2*(1/T2*) maps, using measurements from ex vivo imaging as the reference standard. Results Phantom studies confirmed HDR-QSM's accurate iron content quantification and artifact mitigation ability by revealing a strong linear relationship between iron concentration and QSM values (R2, 0.98). In in vivo studies, HDR-QSM showed significantly improved image quality and susceptibility homogeneity in nonaffected myocardium by alleviating motion and off-resonance artifacts (HDR-QSM vs R2*: coefficient of variation, 0.31 ± 0.16 [SD] vs 0.73 ± 0.36 [P < .001]; image quality score [five-point Likert scale:], 3.58 ± 0.75 vs 2.87 ± 0.51 [P < .001]). Comparison between in vivo susceptibility maps and ex vivo measurements showed higher performance of HDR-QSM compared with R2* mapping for IMH detection (area under the receiver operating characteristic curve, 0.96 vs 0.75; P < .001) and iron content quantification (R2, 0.71 vs 0.14). Conclusion In a canine model of IMH, the fast and free-running cardiac QSM technique accurately detected IMH and quantified intramyocardial iron content of the entire heart within 5 minutes without requiring breath holding. Keywords: High-Dynamic-Range Quantitative Susceptibility Mapping, Myocardial Infarction, Intramyocardial Hemorrhage, MRI Supplemental material is available for this article. ©RSNA, 2024.
快速、自由运行、心脏定量易感性制图的准确心内出血评估。
目的评价高动态范围定量敏感性制图(HDR-QSM)心脏MRI技术在检测心肌内出血(IMH)和定量铁含量方面的应用。材料与方法建立了一种自由运行全心HDR-QSM评估方法,并在校准的铁模型和14只IMH雌性犬模型上进行了评估。以离体成像测量值为参考标准,将该技术的IMH检测和铁含量定量性能与常规铁成像方法R2*(1/T2*)图进行比较。结果幻影研究通过揭示铁浓度与QSM值之间的强线性关系(R2, 0.98)证实了HDR-QSM的准确铁含量定量和伪影缓解能力。在体内研究中,HDR-QSM通过减轻运动和非共振伪影,显著改善了未受影响心肌的图像质量和敏感性均匀性(HDR-QSM vs R2*:变异系数:0.31±0.16 [SD] vs 0.73±0.36 [P < .001];图像质量评分[五点李克特量表],3.58±0.75 vs 2.87±0.51 [P < .001])。体内敏感性图与离体敏感性图的比较表明,与R2*作图相比,HDR-QSM检测IMH的性能更高(接收器工作特性曲线下面积,0.96 vs 0.75;P < 0.001)和铁含量定量(R2, 0.71 vs 0.14)。结论在犬IMH模型中,快速自由运行心脏QSM技术可以在不需要屏气的情况下准确检测IMH并在5分钟内定量整个心脏的心肌内铁含量。关键词:高动态范围定量敏感性制图,心肌梗死,心内出血,MRI©RSNA, 2024年。
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