Spatial analysis of cholangiocarcinoma in Thailand from 2012 to 2021; a population-based cancer registries study.

IF 2.6 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

PLoS ONE Pub Date : 2024-12-11 eCollection Date: 2024-01-01 DOI:10.1371/journal.pone.0311035

Oraya Sahat, Supot Kamsa-Ard, Apiporn Thinkhamrop Suwannatrai, Apiradee Lim, Siriporn Kamsa-Ard, Surichai Bilheem, Karnchana Daoprasert, Atit Leklob, Surin Uadrang, Chalongpon Santong, Nithima Sriket, Wasan Chansaard

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Abstract

Background: Cholangiocarcinoma (CCA) is major health issue in Thailand, with high incidences in different parts of country. This study examines the association between spatial variables and CCA in Thailand.

Methods: Thailand's four population-based cancer registries provided data for this retrospective cohort analysis between January 1, 2012, and December 31, 2021. 6,379 diagnosed CCA cases were found in 554 sub-districts. Moran's I and Local Indicators of Spatial Association (LISA) measured geographic dispersion and estimated sex age-standardized rates (ASRs). Multivariable log-linear regression assessed geography and CCA, calculating adjusted incidence rate ratios (IRRs) and 95% confidence interval (CI).

Results: Of 6,379 CCA cases, 63.9% were male, and the mean age at diagnosis was 66.2 years (standard deviation = 11.07 years). CCA ASRs for both sexes in Thailand was 8.9 per 100,000 person-years. The northeastern region had the greatest ASR at 13.4 per 100 000 person-years. Moran's I and LISA studies grouped regions by spatial variables. The association between spatial variables and CCA demonstrated that the northern region exhibited elevation (adjusted IRRs = 0.82, 95%CI: 0.78 to 0.87) and distance from water sources variable (adjusted IRRs = 0.91, 95%CI: 0.82 to 0.99). The central region elevation variable (adjusted IRRs = 0.85, 95%CI: 0.76 to 0.94). This was the distance from water sources (adjusted IRRs = 0.96, 95%CI: 0.93 to 0.99) and population density variable (adjusted IRRs = 0.94, 95%CI: 0.93 to 0.96) in the northeastern region. Population density (adjusted IRRs = 1.09, 95%CI: 1.02 to 1.15) and average temperature variable (adjusted IRRs = 1.05, 95%CI: 1.02 to 1.09) were significant in the southern region.

Conclusion: Spatial variables associated with CCA indicate that ASR differs across Thailand. So environmental and climate factors can inform targeted public health strategies to address CCA in high-risk areas throughout Thailand.

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2012 - 2021年泰国胆管癌的空间分析一项基于人群的癌症登记研究。

背景：胆管癌（CCA）是泰国的主要健康问题，在泰国不同地区的发病率都很高。本研究探讨了空间变量与泰国CCA之间的关系。方法：泰国四个基于人群的癌症登记处为2012年1月1日至2021年12月31日期间的回顾性队列分析提供了数据。554个街道共发现确诊CCA病例6379例。Moran's I和Local Indicators of Spatial Association （LISA）测量了地理分布和估计的性别年龄标准化率（ASRs）。多变量对数线性回归评估地理和CCA，计算调整发病率比（IRRs）和95%置信区间（CI）。结果：6379例CCA中，男性占63.9%，平均诊断年龄为66.2岁（标准差为11.07岁）。泰国男女的CCA asr为8.9 / 10万人年。东北地区ASR最高，为13.4 / 10万人年。Moran的I和LISA研究了按空间变量分组的区域。空间变量与CCA的相关性表明，北方地区表现为海拔（调整后的irs = 0.82, 95%CI: 0.78 ~ 0.87）和水源距离（调整后的irs = 0.91, 95%CI: 0.82 ~ 0.99）。中部地区高程变量（调整后的irs = 0.85, 95%CI: 0.76 ~ 0.94）。这两个变量分别是东北地区水源距离（调整后的IRRs = 0.96, 95%CI: 0.93 ~ 0.99）和人口密度（调整后的IRRs = 0.94, 95%CI: 0.93 ~ 0.96）。南方地区人口密度（调整后的irs = 1.09, 95%CI: 1.02 ~ 1.15）和平均气温（调整后的irs = 1.05, 95%CI: 1.02 ~ 1.09）差异显著。结论：与CCA相关的空间变量表明泰国不同地区的ASR存在差异。因此，环境和气候因素可以为有针对性的公共卫生战略提供信息，以解决泰国各地高风险地区的CCA问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PLoS ONE 生物-生物学

CiteScore

6.20

自引率

5.40%

发文量

14242

审稿时长

3.7 months

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