The relationship between demographic factors and brain hierarchical changes following antidepressant treatment in patients remitted from depression

IF 3.7 2区 医学 Q1 PSYCHIATRY
Li Xue , Huan Wang , Xinyi Wang , Junneng Shao , Yurong Sun , Rongxin Zhu , Zhijian Yao , Qing Lu
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Abstract

To investigate the associations between demographic factors and brain hierarchical changes following successful selective serotonin reuptake inhibitor (SSRI) treatment, 57 major depressive disorder (MDD) patients who achieved remission after a 12-week SSRI treatment and 39 healthy controls (HCs) were recruited. MDD patients underwent diffusion tensor imaging (DTI) scans before treatment and after the 12-week SSRI treatment. Depression severity was evaluated with the Hamilton Rating Scale for Depression (HAMD) using the total score and the subscales: retardation, cognitive impairment, anxiety, and sleep disturbance. All HCs also underwent DTI scans after enrollment. Building on gradient mapping techniques, we developed a set of measures to quantify the dispersion within functional communities and also studied demographic-relevant differences in the three-dimensional gradient space of remitted MDD patients. We defined the Z-scores of the gradients in the pre-treatment group relative to the HC group as the disease pattern, post-treatment group relative to the HC group as the recovery pattern. The results showed that the disease pattern of depression is associated with age, as older age groups exhibit more severe impairments in depression. A significant difference was detected in the dispersion of the frontoparietal network (FPN) between pre-treatment and post-treatment patients. With the moderating effect of the age of onset, the dispersion of the FPN was related to the improvement in cognitive impairment, the dorsal attention network (DAN) was related to the improvement in retardation symptoms. Our findings help clinicians be alert to the role of demographic effects on clinical efficacy when treating depressed patients.
抑郁症缓解患者抗抑郁药物治疗后人口统计学因素与脑层级变化的关系。
为了研究人口统计学因素与选择性5 -羟色胺再摄取抑制剂(SSRI)成功治疗后脑分层变化之间的关系,我们招募了57名重度抑郁症(MDD)患者和39名健康对照(hc),这些患者在接受12周的SSRI治疗后获得缓解。MDD患者在治疗前和治疗12周后接受弥散张量成像(DTI)扫描。采用汉密尔顿抑郁评定量表(HAMD)评定抑郁症的严重程度,包括总分和智力迟钝、认知障碍、焦虑和睡眠障碍等子量表。所有hc在入组后也进行了DTI扫描。在梯度映射技术的基础上,我们开发了一套量化功能社区内离散度的措施,并研究了缓解型重度抑郁症患者三维梯度空间中的人口统计学相关差异。我们将治疗前组相对于HC组的梯度z分数定义为疾病模式,治疗后组相对于HC组的梯度z分数定义为恢复模式。结果表明,抑郁症的疾病模式与年龄有关,因为年龄越大的年龄组在抑郁症方面表现出更严重的损害。在治疗前和治疗后的患者中,检测到额顶叶网络(FPN)的离散性有显著差异。在发病年龄的调节作用下,FPN的分散与认知障碍的改善有关,背侧注意网络(DAN)与发育迟缓症状的改善有关。我们的发现有助于临床医生在治疗抑郁症患者时警惕人口统计学效应在临床疗效中的作用。
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来源期刊
Journal of psychiatric research
Journal of psychiatric research 医学-精神病学
CiteScore
7.30
自引率
2.10%
发文量
622
审稿时长
130 days
期刊介绍: Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;
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