Diagnostic Performance of Multiparametric MRI for Detection of Prostate Cancer After Focal Therapy.

IF 1 4区 医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Robert D Petrocelli, Barun Bagga, Sooah Kim, Vinay Prabhu, Kun Qian, Ezequiel Becher, Samir S Taneja, Angela Tong
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引用次数: 0

Abstract

Background: Minimally invasive focal therapy of low- to intermediate-risk prostate cancer is becoming more common and has demonstrated lower morbidity compared to other treatments. Multiparametric prostate magnetic resonance imaging (mpMRI) has the potential to be an effective posttreatment evaluation method for residual/recurrent neoplasm.

Objective: This study aimed to evaluate the ability of mpMRI to detect residual/recurrent neoplasm after focal therapy treatment of prostate cancer using a 3-point Likert scale.

Methods: This retrospective study included patients who underwent focal therapy utilizing cryoablation, high-frequency ultrasound, and radiofrequency ablation for low- to intermediate-risk prostate cancer with baseline mpMRI and biopsy and a 6- to 12-month follow-up mpMRI and biopsy. Three abdominal fellowship-trained readers were asked to evaluate the follow-up mpMRI utilizing a 3-point Likert scale based on the level of suspicion as "nonviable," "equivocal," or "viable." Diagnostic statistics and Light's κ for interreader variability were calculated.

Results: A total of 142 patients were included (mean age, 65 ± 7 years). When considering "equivocal" or "viable" as positive, the overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the receiver operating characteristic curve (AUC) for detecting recurrent grade group (GG) 2 or greater disease for Reader 1 were 0.47, 0.83, 0.24, 0.93, and 0.65; for Reader 2, 0.73, 0.75, 0.26, 0.96, and 0.74; and for Reader 3, 0.73, 0.57, 0.17, 0.95, and 0.65. When considering "viable" as positive, the overall sensitivity, specificity, PPV, NPV, and AUC for Reader 1 were 0.47, 0.92, 0.41, 0.94, and 0.69; for Reader 2, 0.33, 0.97, 0.56, 0.93, and 0.65; and for Reader 3, 0.53, 0.84, 0.29, 0.94, and 0.69. κ was 0.39.

Conclusions: This study suggests that DCE and DWI are the most important sequences in mpMRI and demonstrates the efficacy of utilizing a 3-point grading system in detecting and diagnosing prostate cancer after focal therapy.

Clinical impact: mpMRI can be used to monitor for residual/recurrent disease after focal therapy.

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来源期刊
CiteScore
2.50
自引率
0.00%
发文量
230
审稿时长
4-8 weeks
期刊介绍: The mission of Journal of Computer Assisted Tomography is to showcase the latest clinical and research developments in CT, MR, and closely related diagnostic techniques. We encourage submission of both original research and review articles that have immediate or promissory clinical applications. Topics of special interest include: 1) functional MR and CT of the brain and body; 2) advanced/innovative MRI techniques (diffusion, perfusion, rapid scanning); and 3) advanced/innovative CT techniques (perfusion, multi-energy, dose-reduction, and processing).
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