Mariam Abdelghaffar, José Luis Güell, Nuno Moura-Coelho
{"title":"Topical losartan ophthalmic drops - a review of corneal wound healing and topical losartan for managing corneal haze and potential future indications.","authors":"Mariam Abdelghaffar, José Luis Güell, Nuno Moura-Coelho","doi":"10.1007/s00417-024-06710-8","DOIUrl":null,"url":null,"abstract":"<p><p>Corneal haze, a consequence of pathological wound healing, manifests as opacity and sometimes irregularity impairing vision. This condition arises from breaches in the epithelial barrier, triggering an inflammatory cascade culminating in myofibroblasts formation. Surgical procedures such as photorefractive keratectomy (PRK), laser in situ keratomileusis (LASIK) and corneal cross-linking (CXL) are major contributors, alongside non-surgical causes like trauma and infections. Research has extensively explored post-surgical corneal haze, focusing on the transforming growth factor beta (TGFβ) pathway, inflammation management, and extracellular matrix remodeling. Losartan, traditionally an antihypertensive, has gained attention in ophthalmology for its anti-fibrotic and anti-inflammatory properties. Studies have supported its efficacy in reducing corneal fibrosis post-descemetorhexis, alkali burn, and PRK injuries in animal models, and human case reports. This review aims to examine the topical use of losartan 0.08% in ophthalmology, assessing its effectiveness against post-surgical corneal haze and exploring its pharmacological profile and potential future applications. We provide a systematic review of all published in-human studies of the use of topical losartan in corneal disease.</p>","PeriodicalId":12795,"journal":{"name":"Graefe’s Archive for Clinical and Experimental Ophthalmology","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Graefe’s Archive for Clinical and Experimental Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00417-024-06710-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Corneal haze, a consequence of pathological wound healing, manifests as opacity and sometimes irregularity impairing vision. This condition arises from breaches in the epithelial barrier, triggering an inflammatory cascade culminating in myofibroblasts formation. Surgical procedures such as photorefractive keratectomy (PRK), laser in situ keratomileusis (LASIK) and corneal cross-linking (CXL) are major contributors, alongside non-surgical causes like trauma and infections. Research has extensively explored post-surgical corneal haze, focusing on the transforming growth factor beta (TGFβ) pathway, inflammation management, and extracellular matrix remodeling. Losartan, traditionally an antihypertensive, has gained attention in ophthalmology for its anti-fibrotic and anti-inflammatory properties. Studies have supported its efficacy in reducing corneal fibrosis post-descemetorhexis, alkali burn, and PRK injuries in animal models, and human case reports. This review aims to examine the topical use of losartan 0.08% in ophthalmology, assessing its effectiveness against post-surgical corneal haze and exploring its pharmacological profile and potential future applications. We provide a systematic review of all published in-human studies of the use of topical losartan in corneal disease.
期刊介绍:
Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.