Interictal epileptiform discharge-related BOLD responses in the default mode network and subcortical regions.

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2024-12-05 DOI:10.1016/j.clinph.2024.11.017

Satoru Ikemoto, Nicolás von Ellenrieder, Jean Gotman

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引用次数: 0

Abstract

Objective: To examine the blood oxygen level-dependent (BOLD) responses in the default mode network (DMN) and subcortical regions in relation to epileptic events in scalp EEG and intracranial EEG (iEEG).

Methods: We retrospectively compared BOLD responses in the DMN and subcortical regions to interictal epileptiform discharge (IED) characteristics of the scalp and iEEG in consecutive patients with focal epilepsy. All voxels were used as the denominator to assess the positive and negative BOLD ratios in each region, and the percentage of voxels with significant activation or deactivation was assessed.

Results: Seventy-one EEG-fMRI studies were included. The widespread IED group showed a higher negative BOLD ratio in the DMN than did the focal IED group. Spike and ripple spreads in iEEG positively correlated with a positive BOLD ratio in the DMN and subcortical regions and a negative BOLD ratio in the DMN. Fast ripple spread showed no correlation with the BOLD ratio in any region.

Conclusions: IEDs affect local regions, as well as distant neocortical (DMN) and subcortical regions, depending on their localization and characteristics.

Significance: Our findings showed both positive and negative IED-related BOLD responses in subcortical regions and new evidence of network dysfunction related to focal epileptic activity.

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.