Fibromyalgia severity and symptoms are associated with the disorders of gut–brain interaction

IF 3.5 2区医学 Q1 ANESTHESIOLOGY

European Journal of Pain Pub Date : 2024-12-12 DOI:10.1002/ejp.4766

Sharon Erdrich, Joanna E. Harnett

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Abstract

Introduction

Fibromyalgia remains an idiopathic common disorder characterised by widespread pain with no universally accepted treatment. Irritable bowel syndrome is prevalent among women living with fibromyalgia. The prevalence of other disorders of gut–brain interaction (DGBI) and associations with fibromyalgia symptoms and severity is unknown.

Objectives

To evaluate the prevalence of the range of DGBI and associations with the symptoms and severity of fibromyalgia in women.

Methods

A prospective observational study was conducted in New Zealand in 2022. A comprehensive survey included validated measures to identify DGBI (Rome IV) and items assessing the severity of fibromyalgia and pain symptoms, sleep quality, quality of life, mental health and migraine. Analysis was conducted employing Spearman's rho, Mann–Whitney U, Kruskal–Wallis and chi-square tests.

Results

A total of 111 adult women with fibromyalgia enrolled in the study. Of these, 98 (93%) met the criteria for at least one DGBI, and 67 (68%) satisfied criteria for more than one. All groups of DGBI, and 11 specific DGBI were significantly associated with measures of pain, fibromyalgia severity, sleep problems and migraine (p < 0.05). Severity of pain and symptoms associated with fibromyalgia, including sleep problems, were also significantly associated with the functional bowel disorder severity index.

Conclusion

This study demonstrated that the prevalence of DGBI in women with fibromyalgia extends beyond irritable bowel syndrome. Presence of multiple DGBI correlates with pain, severity indices of fibromyalgia and sleep problems. Further research is required to examine the aetiology of DGBI in this population.

Significance Statement

This observational study has identified important relationships between the broader DGBI, fibromyalgia pain and associated symptoms, particularly migraine and sleep disturbance. Notable correlations between the severity indices of each are demonstrated, suggesting that improvements in one domain may reduce pain and improve overall well-being. These findings highlight the importance of addressing each clinical feature of the condition when supporting patients with fibromyalgia.

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纤维肌痛的严重程度和症状与肠-脑相互作用紊乱有关。

简介：纤维肌痛仍然是一种特发性常见疾病，其特征是广泛的疼痛，没有普遍接受的治疗。肠易激综合症在患有纤维肌痛的女性中很普遍。其他肠-脑相互作用疾病（DGBI）的患病率以及与纤维肌痛症状和严重程度的关联尚不清楚。目的：评估DGBI范围的流行程度及其与女性纤维肌痛症状和严重程度的关系。方法：2022年在新西兰进行前瞻性观察研究。一项全面调查包括确定DGBI （Rome IV）的有效措施，以及评估纤维肌痛和疼痛症状严重程度、睡眠质量、生活质量、心理健康和偏头痛的项目。采用Spearman’s rho、Mann-Whitney U、Kruskal-Wallis检验和卡方检验进行分析。结果：共有111名患有纤维肌痛的成年女性参加了这项研究。其中98例（93%）符合至少一种DGBI的标准，67例（68%）满足一种以上DGBI的标准。所有DGBI组和11种特异性DGBI与疼痛、纤维肌痛严重程度、睡眠问题和偏头痛的测量结果显著相关(p结论：本研究表明DGBI在纤维肌痛女性患者中的患病率超出了肠易激综合征。多重DGBI的存在与疼痛、纤维肌痛的严重程度指数和睡眠问题相关。需要进一步的研究来检查DGBI在这一人群中的病因。意义声明：这项观察性研究已经确定了更广泛的DGBI、纤维肌痛和相关症状，特别是偏头痛和睡眠障碍之间的重要关系。每个严重程度指数之间的显著相关性被证明，这表明一个领域的改善可能会减轻疼痛并改善整体幸福感。这些发现强调了在支持纤维肌痛患者时解决每个临床特征的重要性。

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来源期刊

European Journal of Pain 医学-临床神经学

CiteScore

7.50

自引率

5.60%

发文量

163

审稿时长

4-8 weeks

期刊介绍： European Journal of Pain (EJP) publishes clinical and basic science research papers relevant to all aspects of pain and its management, including specialties such as anaesthesia, dentistry, neurology and neurosurgery, orthopaedics, palliative care, pharmacology, physiology, psychiatry, psychology and rehabilitation; socio-economic aspects of pain are also covered. Regular sections in the journal are as follows: • Editorials and Commentaries • Position Papers and Guidelines • Reviews • Original Articles • Letters • Bookshelf The journal particularly welcomes clinical trials, which are published on an occasional basis. Research articles are published under the following subject headings: • Neurobiology • Neurology • Experimental Pharmacology • Clinical Pharmacology • Psychology • Behavioural Therapy • Epidemiology • Cancer Pain • Acute Pain • Clinical Trials.