A pilot study of the relationship between salivary microbial characteristics and endocrine and immune function in patients with burning mouth syndrome.

IF 3.1 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Investigations Pub Date : 2024-12-12 DOI:10.1007/s00784-024-06102-6

Qianqian Zhang, Xinghan Li, Zhiyi Wang, Shijiao Shen, Junzhe Wang, Junyang Chen, Xiaoran Shi, Shichen Wang, Jun Cao, Yongqiang Deng, He Meng, Lin Ma

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引用次数: 0

Abstract

Objectives: To explore the potential role of oral bacteria in the pathogenesis of burning mouth syndrome (BMS).

Materials and methods: Fifteen patients with BMS and 15 healthy controls were enrolled in this study. The relative abundance and diversity of salivary bacterial strains were analyzed using metagenomic DNA sequencing. The functionality of non-redundant genes was obtained by comparing the mmseqs2 with the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. BMS relating salivary protein markers were detected using enzyme-linked immunosorbent assay (ELISA).

Results: Partial least-squares discriminant analysis (PLS-DA) revealed that the salivary bacterial profiles of the BMS group (mean age: 38.9 ± 2.2 years) differed significantly from those of the control group (mean age: 34.1 ± 2.3 years) in terms of the abundance of dominant phyla, classes, orders, families, genera and species. Functional analysis revealed distinct endocrine and immune functions in the BMS group. The salivary cortisol and α-amylase levels were significantly higher, and salivary interleukn-6 levels were significantly lower in the BMS group than in the control group. Species contribution analysis of endocrine and immune functions revealed that Streptococcus mitis was an important contributor to endocrine and immune functions in the BMS group.

Conclusions: Salivary dysbiosis related to endocrine and immune functions may be a possible cause of BMS.

Clinical relevance: These findings could assist in the diagnosis and therapy of BMS.

Clinical trial number: Not applicable.

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来源期刊

Clinical Oral Investigations 医学-牙科与口腔外科

CiteScore

6.30

自引率

5.90%

发文量

484

审稿时长

3 months

期刊介绍： The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.