The Association between Sarcopenia and Constipation Onset in Community-dwelling Older Adults in Japan.

IF 1 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
Hiroaki Nakagawa, Taro Takeshima, Akihiro Ozaka, Sho Sasaki, Sugihiro Hamaguchi, Shunichi Fukuhara
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引用次数: 0

Abstract

Objective Constipation is an important symptom in older adults. Sarcopenia is associated with constipation, but its directionality remains unclear. The present study assessed the association between sarcopenia and new-onset constipation. Methods This prospective cohort study assessed sarcopenia at baseline in 2019 using the SARC-F questionnaire. Sarcopenia was defined as a SARC-F score of ≥4. Constipation was measured in 2019 and 2020 based on self-reported constipation or laxative use, using a self-administered questionnaire. Logistic regression was used to estimate the association between new-onset constipation in 2020 and sarcopenia status at the baseline. Patients Independent community-dwelling adults ≥75 years old in Sukagawa City, Fukushima, Japan. Results The analysis included 2,388 participants without constipation at baseline (mean age: 80.0±4.3 years old; 44.9% men), of whom 310 (13.0%) had sarcopenia at baseline. Overall, 262 participants (11.0%) developed constipation, including 57 of 310 (18.4%) with sarcopenia and 205 of 2,078 (9.9%) without sarcopenia. Participants with sarcopenia had a significantly higher risk of developing constipation than those without sarcopenia after adjusting for age, sex, lifestyle factors, and comorbidities (adjusted odds ratio, 1.98; 95% confidence interval, 1.40-2.81; P <0.001). The association between sarcopenia and new-onset constipation remained statistically significant at higher and lower SARC-F cutoff values. Conclusion Sarcopenia was associated with new-onset constipation. Sarcopenia is a risk factor for constipation in independent community-dwelling older adults ≥75 years old. Measures addressing sarcopenia may help prevent constipation in older adults.

日本社区老年人肌肉减少症与便秘之间的关系
目的便秘是老年人的重要症状。肌肉减少症与便秘有关,但其方向性尚不清楚。本研究评估了肌肉减少症与新发便秘之间的关系。方法本前瞻性队列研究使用SARC-F问卷评估2019年基线时的肌肉减少症。SARC-F评分≥4时定义为肌肉减少症。在2019年和2020年,根据自我报告的便秘或泻药使用情况,使用自我管理的问卷来测量便秘情况。使用Logistic回归来估计2020年新发便秘与基线时肌肉减少症状态之间的关系。患者为日本福岛须贺川市≥75岁的独立社区居住成年人。结果分析包括2,388名基线时无便秘的参与者(平均年龄:80.0±4.3岁;44.9%男性),其中310人(13.0%)在基线时患有肌肉减少症。总体而言,262名参与者(11.0%)出现便秘,其中310名参与者中有57名(18.4%)患有肌肉减少症,2078名参与者中有205名(9.9%)没有肌肉减少症。在调整了年龄、性别、生活方式因素和合并症后,肌肉减少症患者发生便秘的风险明显高于没有肌肉减少症的患者(调整优势比,1.98;95%置信区间为1.40-2.81;P
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Internal Medicine
Internal Medicine 医学-医学:内科
CiteScore
1.90
自引率
8.30%
发文量
0
审稿时长
2.2 months
期刊介绍: Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.
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