The Effects of Weight Loss and Aerobic Exercise on Cortisol and Cortisol Suppression in Postmenopausal Women with Overweight and Obesity.

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrine Research Pub Date : 2024-12-12 DOI:10.1080/07435800.2024.2439408

Alice S Ryan, Monica C Serra, Galya Bigman, Sausan Jaber

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引用次数: 0

Abstract

Purpose: The goal of this study was to explore the complex relationship between obesity, dietary content, weight loss, and cortisol concentrations in postmenopausal women with overweight and obesity.

Methods: Women completed basal cortisol testing, a dexamethasone suppression test (DST), DXA scan, 3-hour oral glucose tolerance test (OGTT), and food records before (n = 60) and a subset after 6-months of weight loss (WL; n = 15) or aerobic exercise training+weight loss (AEX+WL, n = 34).

Results: At baseline, plasma cortisol concentrations decreased significantly after DST in the entire group, a 54% suppression which was associated with basal glucose. Basal glucose levels and glucose AUC from the OGTT are associated with basal cortisol levels (r = 0.44 and r = 0.29, p < 0.05 respectively). The intervention resulted in significant weight loss (-8%) but no significant changes in basal cortisol or changes in cortisol from basal to DST were observed.

Conclusion: Additional research is necessary to better comprehend cortisol regulation in postmenopausal women particularly in response to effective weight reduction interventions.

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减肥和有氧运动对绝经后超重和肥胖妇女皮质醇和皮质醇抑制的影响。

目的：本研究的目的是探讨绝经后超重和肥胖妇女肥胖、饮食含量、体重减轻和皮质醇浓度之间的复杂关系。方法：女性完成了基础皮质醇测试、地塞米松抑制试验（DST）、DXA扫描、3小时口服葡萄糖耐量试验（OGTT）和减肥前（n = 60）和减肥后6个月(WL；n = 15)或有氧运动训练+减肥（AEX+WL, n = 34）。结果：在基线时，整个组的血浆皮质醇浓度在DST后显著下降，降低了54%，这与基础葡萄糖有关。基础葡萄糖水平和OGTT的葡萄糖AUC与基础皮质醇水平相关（r = 0.44和r = 0.29, p）结论：需要进一步的研究来更好地了解绝经后妇女的皮质醇调节，特别是对有效减肥干预的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.