Distribution and Drug Resistance of Pathogens of Catheter-Related Blood Stream Infection in a Hospital from 2017 to 2021.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2024-12-01 DOI:10.7754/Clin.Lab.2024.240514

Panpan Sun, Jiyong Jian, Liang Chen

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引用次数: 0

Abstract

Background: We analyzed the clinical distribution and the antibiotic susceptibility of pathogens for catheter-related blood stream infection (CRBSI) in the hospital retrospectively.

Methods: The clinical information and pathogens associated with CRBSI were collected from the Microbiology Laboratory of the hospital retrospectively from January 2017 to December 2021. Identification and the antibiotic susceptibility test (AST) were carried out with VITEK-2 Compact. The data were analyzed by WHONET 5.6.

Results: A total of 138 isolates (6.4%) associated with CRBSI were found during the 5-year period. Among the pathogens of CRBSI, 89 (64.5%) isolates were coagulase-negative Staphylococcus, 6 (4.3%) were strains of Enterococcus, and 4 (2.9%) were strains of Staphylococcus aureus. Staphylococci and Streptococci were all sensitive to Linezolid, Vancomycin, Quinuprine/Dafuprine, and Tigecycline. There were 39 (28.3%) Gram-negative bacilli isolates, including 17 strains of Klebsiella pneumoniae (12.3%), 6 (4.3%) strains of Acinetobacter baumannii, and 6 (4.3%) strains of Burkholderia cepacia. The drug resistance rates of Gram-negative bacilli to most drugs were higher than 50%. The main departments where CRBSI pathogens were isolated were Peritoneal Tumor Surgery (86, 62.3%), ICU (20, 14.5%), Emergency Department (6, 4.3%), and Respiratory Department (6, 4.3%).

Conclusions: With the emergence of multidrug-resistant (MDR) bacteria, more attention should be paid to the prevention and control of nosocomial infections. At the same time, the use and management of antibiotics should be standardized, and monitoring of multidrug-resistant bacteria should be strengthened in hospitals.

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2017 - 2021年某医院导管相关血流感染病原菌分布及耐药性分析

背景：回顾性分析医院导管相关性血流感染（CRBSI）病原菌的临床分布及药敏情况。方法：回顾性收集2017年1月至2021年12月该院微生物学实验室CRBSI相关临床资料及病原菌。用VITEK-2 Compact进行鉴定和药敏试验（AST）。数据采用WHONET 5.6进行分析。结果：5年间共分离出138株（6.4%）与CRBSI相关。CRBSI病原菌中凝固酶阴性葡萄球菌89株（64.5%）、肠球菌6株（4.3%）、金黄色葡萄球菌4株（2.9%）。葡萄球菌和链球菌对利奈唑胺、万古霉素、喹嘌呤/达福嘌呤和替加环素均敏感。革兰氏阴性杆菌39株（28.3%），其中肺炎克雷伯菌17株（12.3%）、鲍曼不动杆菌6株（4.3%）、洋葱伯克霍尔德菌6株（4.3%）。革兰氏阴性杆菌对大部分药物的耐药率均大于50%。CRBSI病原菌分离的主要科室为腹膜肿瘤外科（86例，62.3%）、ICU（20例，14.5%）、急诊科（6例，4.3%）、呼吸科（6例，4.3%）。结论：随着耐多药细菌（MDR）的出现，应重视医院感染的预防和控制。同时，规范抗菌药物的使用和管理，加强医院耐多药菌的监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.