Associations Between Maternal Periconceptional Alcohol Consumption and Risk of Craniosynostosis Among Offspring, National Birth Defects Prevention Study, 1997–2011

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2024-12-12 DOI:10.1002/bdr2.2420

Sarah C. Fisher, Paul A. Romitti, Melissa Tracy, Meredith M. Howley, Ethylin Wang Jabs, Marilyn L. Browne, the National Birth Defects Prevention Study

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引用次数: 0

Abstract

Background

Previous studies of maternal alcohol consumption and craniosynostosis have reported null or inverse associations. We updated a previous analysis of National Birth Defects Prevention Study (NBDPS) data to further examine associations between maternal alcohol consumption and craniosynostosis.

Methods

NBDPS was a multi-site, population-based case–control study. Mothers of craniosynostosis cases and randomly selected liveborn controls delivered during 1997–2011 completed a telephone interview about pregnancy exposures. We examined associations for self-reported periconceptional maternal alcohol consumption (during the month before conception through the third gestational month) and odds of craniosynostosis in offspring. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between any alcohol consumption and binge consumption and craniosynostosis, overall and by affected suture. Finally, we performed a probabilistic bias analysis using a range of assumptions about the sensitivity and specificity of self-reported consumption by case/control status.

Results

We analyzed interview data from 1435 mothers of craniosynostosis cases and 11,216 mothers of controls. Periconceptional alcohol consumption prevalence was similar among case (36.9%) and control (38.2%) mothers. We observed point estimates near or below 1.0 for alcohol consumption (any and binge) and all suture subtypes of craniosynostosis, with all CIs including the null. Our bias-adjusted estimates for periconceptional alcohol consumption were higher than our conventional estimates but supported the null findings.

Conclusions

We observed primarily null associations between maternal periconceptional alcohol consumption and craniosynostosis. However, our findings do not diminish the prevailing clinical guidance in the United States that pregnant people should abstain from alcohol consumption.

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母亲孕期饮酒与后代颅缝闭合风险的关系，国家出生缺陷预防研究，1997-2011。

背景：以往关于母亲饮酒与颅缝闭合的研究报道了零关联或负相关。我们更新了先前对国家出生缺陷预防研究（NBDPS）数据的分析，以进一步研究母亲饮酒与颅缝闭合之间的关系。方法：NBDPS是一项多地点、基于人群的病例对照研究。在1997-2011年期间分娩的颅缝闭合病例的母亲和随机选择的活产对照者完成了关于妊娠暴露的电话采访。我们研究了自我报告的母体孕期饮酒（受孕前一个月至妊娠第三个月）与后代颅缝闭锁几率的关系。我们使用逻辑回归来估计任何饮酒和暴饮与颅缝闭合之间的比值比（ORs）和95%置信区间（CIs），总体上和受影响的缝合。最后，我们使用一系列关于病例/控制状态下自我报告消费的敏感性和特异性的假设进行了概率偏差分析。结果：我们分析了1435例颅缝闭合母亲和11216例对照组母亲的访谈数据。病例母亲（36.9%）和对照组母亲（38.2%）围孕期饮酒患病率相似。我们观察到饮酒（任意和暴饮）和所有缝合型颅缝闭合的点估计值接近或低于1.0，所有ci包括零值。我们对围孕期酒精摄入量的偏倚调整估计值高于我们的常规估计值，但支持无效发现。结论：我们观察到孕妇孕期饮酒与颅缝闭闭之间的关联基本为零。然而，我们的发现并没有削弱美国流行的临床指导，即孕妇应该戒酒。

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.