Assessment of Subacute Toxicity of Ulexite in Rats: Behavioral, Hematological, and Biochemical Insights.

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biological Trace Element Research Pub Date : 2024-12-12 DOI:10.1007/s12011-024-04489-7

Hasan Türkez, Özlem Özdemir Tozlu, Edanur Yıldız, Melik Saraçoğlu, Cem Baba, Burak Çınar, Serkan Yıldırım, Metin Kılıçlıoğlu, Kübra Çelik Topkara, Kenan Çadırcı

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Abstract

Ulexite (UX), a naturally occurring borate mineral, has gained interest for its diverse industrial applications, yet its toxicological profile remains inadequately characterized. This study aimed to evaluate the subacute toxicity of UX in rats, focusing on behavioral, hematological, and biochemical parameters. Rats were administered UX via gavage at doses of 10, 30, and 300 mg/kg for 7 days. No mortality or significant signs of toxicity were observed, although body weight measurements indicated a notable reduction in the UX-treated groups compared to controls. Behavioral assessments demonstrated increased exploratory activity in the 10 and 300 mg/kg UX treated groups, suggesting low anxiety levels. Likewise, hematological analysis revealed that 30 and 300 mg/kg UX led a significant (P < 0.001) increase in hematocrit and a decrease in mean corpuscular hemoglobin concentration (P < 0.001), indicating potential changes in erythropoiesis. Additionally, serum biochemistry showed elevated aspartate aminotransferase (P < 0.05), lactate dehydrogenase (P < 0.001), and uric acid levels (P < 0.01), suggesting liver stress. Histopathological examinations indicated dose-dependent alterations, with mild hepatocellular degeneration and neuronal changes observed at the highest dose. Also, MN levels in the blood of rats exposed to 10 and 30 mg/kg UX showed no significant differences. These results suggest that UX is relatively safe at lower doses, though higher exposures may pose health risks. Further research is warranted to elucidate the mechanisms underlying UX-induced effects and to evaluate its safety for therapeutic and occupational applications.

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大鼠亚急性毒性评价：行为学、血液学和生化观察。

Ulexite （UX）是一种天然存在的硼酸盐矿物，因其多种工业应用而引起了人们的兴趣，但其毒理学特征仍不充分。本研究旨在评估UX对大鼠的亚急性毒性，重点关注行为学，血液学和生化参数。大鼠分别以10、30和300 mg/kg的剂量灌胃UX，持续7天。没有观察到死亡或明显的毒性迹象，尽管体重测量表明，与对照组相比，ux治疗组明显减少。行为评估显示，10和300 mg/kg UX治疗组的探索活动增加，表明焦虑水平较低。同样，血液学分析显示，30和300 mg/kg UX导致显著(P

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来源期刊

Biological Trace Element Research 生物-内分泌学与代谢

CiteScore

8.70

自引率

10.30%

发文量

459

审稿时长

2 months

期刊介绍： Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.