A platform of gold nanoparticles coated with silica as controlled drug delivery for application in cancer treatment

IF 3.5 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Journal of Materials Science Pub Date : 2024-12-04 DOI:10.1007/s10853-024-10490-1

Isabela Barreto da Costa Januário Meireles, André Felipe Oliveira, Michele Angela Rodrigues, Edésia Martins Barros de Sousa

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引用次数: 0

Abstract

The optical properties of gold nanoparticles are widely investigated with interest in their application in photohyperthermia cancer treatments. Coating these nanoparticles with MCM-41 silica not only protects the gold nanoparticles but also has the potential for use as a nanocarrier, because of its textural properties. This nanocarrier allows the incorporation of drugs, such as methotrexate (MTX), for use in chemotherapy. Therefore, this nanoplatform shows promise for the treatment of cancer by photohyperthermia and chemotherapy, making the therapy more targeted and effective. This study aimed to investigate the incorporation and release of MTX from a nanoplatform of gold nanoparticles coated with MCM-41, which presents relevant properties for application in photohyperthermia treatments. The results showed that the proposed nanosystem has high cell viability and low cytotoxicity, indicating its potential for application in biological systems. Furthermore, our findings demonstrated that FITC-conjugated MCM-41 nanoparticles were internalized by the cells. Additionally, it was observed that nanomaterials containing MTX showed high cytotoxicity only to tumor cells and that these nanocarriers were taken up by cells, suggesting their specificity in cancer treatment. The synthesized nanocomposite shows promise for applications in cancer treatment through photohyperthermia and chemotherapy.

Graphical abstract

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一种包覆二氧化硅的金纳米颗粒平台，用于癌症治疗中的药物控制

金纳米粒子的光学性质被广泛研究，其在光热治疗癌症方面的应用备受关注。用MCM-41二氧化硅涂覆这些纳米颗粒不仅可以保护金纳米颗粒，而且由于其结构特性，还具有用作纳米载体的潜力。这种纳米载体允许掺入药物，如用于化疗的甲氨蝶呤（MTX）。因此，这种纳米平台有望通过光疗和化疗治疗癌症，使治疗更具针对性和有效性。本研究旨在研究MCM-41包被金纳米粒子的纳米平台中MTX的掺入和释放，并为其在光热治疗中的应用提供相关特性。结果表明，该纳米系统具有高细胞活力和低细胞毒性，在生物系统中具有应用潜力。此外，我们的研究结果表明，fitc缀合的MCM-41纳米颗粒被细胞内化。此外，我们观察到含有MTX的纳米材料仅对肿瘤细胞表现出高细胞毒性，并且这些纳米载体被细胞吸收，这表明它们在癌症治疗中的特异性。合成的纳米复合材料有望通过光疗和化疗应用于癌症治疗。图形抽象

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来源期刊

Journal of Materials Science 工程技术-材料科学：综合

CiteScore

7.90

自引率

4.40%

发文量

1297

审稿时长

2.4 months

期刊介绍： The Journal of Materials Science publishes reviews, full-length papers, and short Communications recording original research results on, or techniques for studying the relationship between structure, properties, and uses of materials. The subjects are seen from international and interdisciplinary perspectives covering areas including metals, ceramics, glasses, polymers, electrical materials, composite materials, fibers, nanostructured materials, nanocomposites, and biological and biomedical materials. The Journal of Materials Science is now firmly established as the leading source of primary communication for scientists investigating the structure and properties of all engineering materials.