Advances in self-powered biomaterials for bone defect repair

IF 21.8 2区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES

Advanced Composites and Hybrid Materials Pub Date : 2024-12-12 DOI:10.1007/s42114-024-01115-x

Nana Shen, Zhihao Zhang, Futong Wu, Zhongze Zhu, Jiarui Liu, Xiaoying Qi, Qiang Li, Xiaoxiong Wang, Qingming Ma, Hongfei Xiang

{"title":"Advances in self-powered biomaterials for bone defect repair","authors":"Nana Shen, Zhihao Zhang, Futong Wu, Zhongze Zhu, Jiarui Liu, Xiaoying Qi, Qiang Li, Xiaoxiong Wang, Qingming Ma, Hongfei Xiang","doi":"10.1007/s42114-024-01115-x","DOIUrl":null,"url":null,"abstract":"<div><p>Bone defects caused by aging populations and accidental injuries have a significant impact on human life, making bone repair and regeneration a research hotspot. The piezoelectric effect in biomaterials has shown great potential in bone defect treatment by converting mechanical stress into electrical signals to promote osteoblast behavior and subsequently accelerate bone regeneration. Electrical stimulation has been proven to improve the interfacial properties of biomaterials, enhancing cell adhesion and growth on the material surface, and promoting bone healing by regulating cellular behavior. With ongoing research on self-powered materials, various electroactive biomaterials have emerged. This review summarizes the mechanisms of bone repair and regeneration under electrical stimulation and the role of self-powered biomaterials in promoting bone regeneration by regulating the microenvironment. We present examples of applications combining biomaterials and electrical stimulation and discuss the challenges and future directions of these strategies for clinical translation. In conclusion, electroactive biomaterials show remarkable promise in bone defect treatment and provide a new therapeutic approach for bone regeneration.</p></div>","PeriodicalId":7220,"journal":{"name":"Advanced Composites and Hybrid Materials","volume":"8 1","pages":""},"PeriodicalIF":21.8000,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s42114-024-01115-x.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Composites and Hybrid Materials","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s42114-024-01115-x","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, COMPOSITES","Score":null,"Total":0}

引用次数: 0

Abstract

Bone defects caused by aging populations and accidental injuries have a significant impact on human life, making bone repair and regeneration a research hotspot. The piezoelectric effect in biomaterials has shown great potential in bone defect treatment by converting mechanical stress into electrical signals to promote osteoblast behavior and subsequently accelerate bone regeneration. Electrical stimulation has been proven to improve the interfacial properties of biomaterials, enhancing cell adhesion and growth on the material surface, and promoting bone healing by regulating cellular behavior. With ongoing research on self-powered materials, various electroactive biomaterials have emerged. This review summarizes the mechanisms of bone repair and regeneration under electrical stimulation and the role of self-powered biomaterials in promoting bone regeneration by regulating the microenvironment. We present examples of applications combining biomaterials and electrical stimulation and discuss the challenges and future directions of these strategies for clinical translation. In conclusion, electroactive biomaterials show remarkable promise in bone defect treatment and provide a new therapeutic approach for bone regeneration.

查看原文本刊更多论文

骨缺损修复用自供电生物材料的研究进展

人口老龄化和意外伤害导致的骨缺损对人类生活产生重大影响，使骨修复与再生成为研究热点。生物材料中的压电效应通过将机械应力转化为电信号来促进成骨细胞行为，从而加速骨再生，在骨缺损治疗中显示出巨大的潜力。电刺激已被证明可以改善生物材料的界面特性，增强细胞在材料表面的粘附和生长，并通过调节细胞行为促进骨愈合。随着对自供电材料的不断研究，各种电活性生物材料已经出现。本文综述了电刺激下骨修复与再生的机制，以及自供电生物材料通过调节微环境促进骨再生的作用。我们提出了结合生物材料和电刺激的应用实例，并讨论了这些策略在临床转化中的挑战和未来方向。总之，电活性生物材料在骨缺损治疗中具有显著的应用前景，为骨再生提供了一种新的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Advanced Composites and Hybrid Materials Multiple-

CiteScore

26.00

自引率

21.40%

发文量

185

期刊介绍： Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field. The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest. Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials. Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.