New 5,6-dihydrobenzo[h]quinoline derivatives as potential demethylase inhibitors (DMIs): design, synthesis, activity evaluation and molecular dynamics simulation

Abstract

Bipolaris maydis is a serious plant fungus and strongly affects the yield and quality of crops. The main control strategy is the employment of fungicides. To research efficient fungicide with novel structure, a series of novel 5,6-dihydrobenzo[h]quinoline derivatives were designed and synthesized.