Photoinduced Cu-Catalyzed C2-H Functionalization of Azoles using Aryl Thianthrenium Salts

Abstract

Development of a mild approach for the highly efficient synthesis of 2-aryl azoles, which are typically synthesized using high temperature, ligands and preactivated substrates, is highly desirable. Here, we report a mild and efficient photo-induced Cu-catalyzed C–H/C–H cross-coupling to obtain C2-functionalized azoles using aryl thianthrenium salt (Ar-TTs). The reaction exhibits a broad substrate scope and an excellent functional group compatibility and serves as an ideal strategy for the late-stage functionalization of pharmaceuticals. Additionally, this method enables the efficient synthesis of azole-based polycyclic compounds.