Decyanative arylation via radical coupling

IF 4.4 2区 化学 Q2 CHEMISTRY, APPLIED
Chenxing Zhou, Xin Zhang, Peiqin Zhang, Congde Huo
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引用次数: 0

Abstract

Arenes, especially heteroarenes, are crucial structural motifs in organic chemistry, pharmaceutical chemistry, and materials science. The introduction of (hetero)aryl groups using readily available feedstocks to modify organic chemicals is a significant topic. Nitriles are ubiquitous and versatile building blocks in organic synthesis. This article summarizes recent advances in decyanative arylation via radical cross-coupling reactions. In these transformations, (hetero)aromatic nitriles undergo one-electron reduction to form persistent radical anion intermediates. Simultaneously, transient carbon centered radicals are generated through cleavage of C–H, C–C, C–X (where X = B, N, Si, S, Br) bonds through single electron transfer or hydrogen atom transfer processes. Finally, a radical-radical coupling reaction followed by CN elimination leads to the formation of aromatized products.
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来源期刊
Advanced Synthesis & Catalysis
Advanced Synthesis & Catalysis 化学-应用化学
CiteScore
9.40
自引率
7.40%
发文量
447
审稿时长
1.8 months
期刊介绍: Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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