Bio-friendly multi-stimuli responsive α-CD polymer-gated mesoporous carbon nanoherbicides for enhanced paraquat delivery

IF 13 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Jiangtao Dong , Guoquan Wang , Xiaona Li , Aohui Han , Wanpeng Zhang , Yuhang Yue , Yue Yang , Yishan Wang , Bowen Yuan , Jiahui Wang , Yuhui Peng , Runqiang Liu , Si Chen , Xuezhong Du
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引用次数: 0

Abstract

Introduction

Weeds seriously affect crop yield in global agricultural production. Paraquat (PQ), as one of low cost and highly effective herbicide, is forbidden or severely restricted in production and sales owing to its lethal toxicity to humans. Creating an efficient and bio-friendly PQ formulation is crucial to facilitate the open use of PQ in world’s agriculture.

Objectives

This study aims to construct one intelligent and bio-friendly mesoporous carbon nanoparticles (MCN) nanoherbicides coated with α-CD polymer (CDP) gatekeepers.

Methods

MCN was prepared through the low-concentration hydrothermal way, calcined and carbonized. PEG stalks were immobilized on MCN surface by amidation reaction. The PQ was trapped in the MCN pores via physical diffusion adsorption and the robust π–π effects between electron-deficient PQ and electron-rich MCN. CDP gatekeepers were fastened via host–guest effects between the chamber of α-CD units and PEG stalks.

Results

The PQ-loaded MCN-PEG@CDP nanoherbicides integrated with multi-stimuli responses to amylase, elevated temperature under sunlight, and competitors at leaf interface to control the PQ release for efficient weed control, while appeared low PQ leakage under the simulated human gastric or intestinal conditions, low cytotoxicity to human normal cells in vitro, and high mouse survival rate in vivo. Even through the nanoherbicides inevitably contact with water or intake by beneficial insects, they appear good biosafety on zebrafish (D. rerio) and honeybees (Apis mellifera L.).

Conclusion

The as-prepared nanoherbicides have high herbicidal efficacy and low risks to non-target species, and could promote the open use of PQ in agriculture.

Abstract Image

Abstract Image

生物友好型多刺激响应α-CD聚合物门控介孔碳纳米除草剂增强百草草的递送
杂草在全球农业生产中严重影响作物产量。百草枯(PQ)作为一种低成本、高效的除草剂,由于其对人体的致命毒性,被禁止或严格限制生产和销售。创造一种高效和生物友好的PQ配方对于促进PQ在世界农业中的开放使用至关重要。目的构建α-CD聚合物(CDP)包被的智能、生物友好型介孔碳纳米除草剂(MCN)。方法采用低浓度水热法制备smcn,煅烧、炭化。通过酰胺化反应将PEG杆固定在MCN表面。贫电子PQ和富电子MCN之间存在π -π效应,通过物理扩散吸附将PQ捕获在MCN孔中。通过α-CD单元腔室与PEG杆之间的主客体效应,固定了CDP守门人。结果负载PQ的MCN-PEG@CDP纳米除草剂综合了淀粉酶、日光下温度升高和叶片界面竞争对手的多重刺激反应,控制PQ释放,有效控制杂草,在模拟人胃或肠道条件下表现出低PQ泄漏,体外对人正常细胞的细胞毒性低,小鼠体内存活率高。尽管纳米除草剂不可避免地与水接触或被益虫摄入,但它们对斑马鱼和蜜蜂具有良好的生物安全性。结论制备的纳米除草剂除草效果好,对非靶种危害小,可促进PQ在农业上的开放利用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Advanced Research
Journal of Advanced Research Multidisciplinary-Multidisciplinary
CiteScore
21.60
自引率
0.90%
发文量
280
审稿时长
12 weeks
期刊介绍: Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.
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