Gut bacterial membrane components as pathogenic signalling molecules in PSC-IBD

IF 26.8 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
David C. Trampert
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引用次数: 0
肠道细菌膜组分在PSC-IBD中的致病信号分子作用
背景和背景原发性硬化性胆管炎(PSC)是一种免疫介导的硬化性胆管病,以胆道树狭窄为特征,与炎症性肠病(IBD)密切相关活动性IBD患者肝移植后PSC复发率较高,结肠切除术对PSC进展有保护作用,这一点得到了强调。“肠-肝轴”信号包括通过受损肠屏障的微生物相关分子。目的、方法和发现作者从肠道细菌中分离出omv,研究了omv向肝脏的迁移能力及其对肝脏的炎症和纤维化作用。他们使用Mdr2-/-小鼠模型来模拟PSC,并通过Mdr2-/-和Casp8ΔIEC小鼠杂交来模拟PSC- ibd在Rosa26中观察了细菌在体内的OMV转运。12 .大肠杆菌或大肠杆菌igfp灌胃接种番茄小鼠模型对于概念验证实验,从肺炎梭菌中分离的omv(发现的意义)dorner等人巧妙地表明,在PSC-IBD模型中,来自psc相关菌株的omv,而不是细菌本身,会转运到肝脏。omv在PSC-IBD中引起致病作用,主要通过肝和胆管的促炎和促纤维化改变。注射omv的Mdr2-/-小鼠和Casp8ΔIECxMdr2-/-小鼠表型相似,提示肠道微生物和炎症信号分子都对肝胆有贡献。资金支持作者没有获得任何资金支持来撰写这篇文章。利益冲突作者声明本工作不存在利益冲突。详情请参阅随附的ICMJE披露表格。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Hepatology
Journal of Hepatology 医学-胃肠肝病学
CiteScore
46.10
自引率
4.30%
发文量
2325
审稿时长
30 days
期刊介绍: The Journal of Hepatology is the official publication of the European Association for the Study of the Liver (EASL). It is dedicated to presenting clinical and basic research in the field of hepatology through original papers, reviews, case reports, and letters to the Editor. The Journal is published in English and may consider supplements that pass an editorial review.
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