Daily glucose variability is associated with intrahepatic fat content, β cell sensitivity, and biomarkers of glycolysis in youth with obesity

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2024-12-10 DOI:10.1002/oby.24175

Emiliano Barbieri, Jacopo Bonet, Delaney Fox, Rafaela Nelson, Michael B. Nelson, Loretta Nelson, Cristina Fernandez, Michelle Van Name, Stephanie Samuels, Sonia Caprio, Mohammad Sabati, Alfonso Galderisi, Jennifer Sherr, Chiara Dalla Man, Nicola Santoro

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引用次数: 0

Abstract

Objective

Pediatric obesity is associated with insulin resistance, which, in turn, impacts glucose and lipid metabolism. This study sought to assess how glucose variability relates to intrahepatic fat content, β cell insulin sensitivity, and glycolysis in youth with obesity.

Methods

A total of 27 youth with obesity (11 girls, BMI percentile, median [25th–75th percentiles]: 99.0 [97.9–99.0]) wore a continuous glucose monitoring device for 10 days and underwent a 3-h oral glucose tolerance test. β cell function was assessed using the oral minimal model, and liver proton density fat fraction was measured by magnetic resonance imaging.

Results

Average sensor-derived glucose and glucose standard deviation (STDEV) and coefficient of variation (CV) were associated with liver proton density fat fraction (p = 0.0130, p = 0.0005, and p = 0.0028, respectively). First-phase insulin secretion, basal insulin secretion, and insulin sensitivity were associated with STDEV (p = 0.0344, p = 0.0091, and p = 0.0031, respectively) and CV (p = 0.0128, p = 0.0012, and p = 0.0022, respectively). STDEV and CV were also associated with 2-h glucose (p = 0.0067 and p = 0.0324, respectively) and plasma lactate (p = 0.0030 and p = 0.0123, respectively).

Conclusions

Daily glucose variability is associated with the degree of intrahepatic fat content, postprandial glucose, and plasma lactate concentrations.

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青少年肥胖患者每日葡萄糖变异性与肝内脂肪含量、β细胞敏感性和糖酵解生物标志物相关。

目的：儿童肥胖与胰岛素抵抗有关，胰岛素抵抗又影响糖脂代谢。本研究旨在评估青少年肥胖患者的葡萄糖变异性与肝内脂肪含量、β细胞胰岛素敏感性和糖酵解的关系。方法：27例肥胖青年（女生11例，BMI百分位数，中位数[25 -75百分位数]:99.0[97.9-99.0]）连续佩戴血糖监测装置10天，并进行3 h口服葡萄糖耐量试验。采用口腔最小模型评估β细胞功能，采用磁共振成像测量肝脏质子密度脂肪分数。结果：平均传感器衍生葡萄糖、葡萄糖标准差（STDEV）和变异系数（CV）与肝质子密度脂肪分数相关（p = 0.0130、p = 0.0005和p = 0.0028）。一期胰岛素分泌、基础胰岛素分泌和胰岛素敏感性与STDEV（分别为p = 0.0344、p = 0.0091和p = 0.0031）和CV（分别为p = 0.0128、p = 0.0012和p = 0.0022）相关。STDEV和CV也与2 h血糖（p = 0.0067和p = 0.0324）和血浆乳酸（p = 0.0030和p = 0.0123）相关。结论：每日葡萄糖变异性与肝内脂肪含量、餐后葡萄糖和血浆乳酸浓度有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.