{"title":"DNA-binding-deficient Hand2 dimerizes with Tcf3a to control zebrafish cardiogenesis","authors":"","doi":"10.1038/s44161-024-00589-8","DOIUrl":null,"url":null,"abstract":"The bHLH transcription factor Hand2 positively regulates pdgfra expression to promote early cardiogenesis in zebrafish. Hand2 can function in this process independently of direct DNA binding by interacting with Tcf3a, another bHLH transcription factor.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"3 12","pages":"1383-1384"},"PeriodicalIF":9.4000,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-024-00589-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
The bHLH transcription factor Hand2 positively regulates pdgfra expression to promote early cardiogenesis in zebrafish. Hand2 can function in this process independently of direct DNA binding by interacting with Tcf3a, another bHLH transcription factor.
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