Effect of diode laser (980 nm) on IL-8 expression in failed endodontic cases: Randomised control trial

IF 1.3 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Australian Endodontic Journal Pub Date : 2024-12-10 DOI:10.1111/aej.12914

Dina Ahmed Morsy BDS, MSc, PhD, Olfat Gameel Shaker BDS, MSc, PhD, Sherif Adel ElKhodary BDS, MSc, PhD

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Abstract

This clinical study assessed the effectiveness of diode laser–980 nm as adjuvant in retreatment of failed endodontic cases with chronic periapical lesions on basis of IL-8 expression and postoperative pain when compared to placebo. For 28 patients, the pre-instrumentation periapical samples (S1) were gathered, following retreatment. After chemo-mechanical preparation, post-instrumentation samples (S2) were collected. Patients were allocated to diode laser (DL) or placebo (PL) groups. After which post-irradiation samples (S3) were gathered. Patients recorded their pain on NRS scale at 6, 12, 24 and 7 days. After 1 week, samples (S4) were collected. An ELISA kit was used to measure an amount of IL-8. DL group showed significantly lower IL-8 levels at S4 (p < 0.001) and postoperative pain at 6 h (p = 0.003) compared to PL. Intracanal diode laser irradiation is a beneficial adjunct to endodontics, in retreatment cases regarding reducing postoperative pain and lowering the level of IL-8 expression.

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二极管激光（980 nm）对牙髓治疗失败患者IL-8表达的影响：随机对照试验

本临床研究根据IL-8的表达和术后疼痛与安慰剂的比较，评估了二极管激光-980 nm作为辅助治疗慢性根尖周围病变失败的根管病例的有效性。对于28例患者，在再次治疗后收集了器械前根尖周样本（S1）。化学机械制备后，采集仪器后样品（S2）。患者被分为二极管激光组（DL）和安慰剂组（PL）。然后收集辐照后样品（S3）。分别于第6、12、24、7天用NRS量表记录疼痛情况。1周后，采集样品（S4）。ELISA试剂盒检测IL-8的含量。DL组在S4时IL-8水平明显降低(p

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来源期刊

Australian Endodontic Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.50

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： The Australian Endodontic Journal provides a forum for communication in the different fields that encompass endodontics for all specialists and dentists with an interest in the morphology, physiology, and pathology of the human tooth, in particular the dental pulp, root and peri-radicular tissues. The Journal features regular clinical updates, research reports and case reports from authors worldwide, and also publishes meeting abstracts, society news and historical endodontic glimpses. The Australian Endodontic Journal is a publication for dentists in general and specialist practice devoted solely to endodontics. It aims to promote communication in the different fields that encompass endodontics for those dentists who have a special interest in endodontics.