Causal Association Between Monounsaturated Fatty Acids and Lung Cancer: A Two-Sample Mendelian Randomization Study

IF 1.9 4区医学 Q3 RESPIRATORY SYSTEM

Clinical Respiratory Journal Pub Date : 2024-12-10 DOI:10.1111/crj.70038

Shaofeng Zhang, Jia Jiang, Xiping Wu, Jiayi Liu, Wei Lei, Siqin Chen, Yaling Zeng, Xiang Liu, Qiang Xiao

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引用次数: 0

Abstract

Objective

This study aims to investigate the potential causal relationship between monounsaturated fatty acids (MUFAs) and lung cancer.

Methods

Genetic data on MUFAs and pathological subtypes of lung cancer were extracted from genome-wide association studies (GWAS). The primary analysis utilized inverse-variance weighted analysis (IVW), with additional methods including the weighted median method, MR-Egger regression method, and weighted model method. Sensitivity analysis was conducted to assess the robustness of the findings.

Results

The inverse variance–weighted (IVW) analysis of monounsaturated fatty acids in relation to lung adenocarcinoma yielded an odds ratio (OR) of 1.059 with a 95% confidence interval of 0.960 to 1.168 and a p value of 0.252. Similarly, for lung squamous cell carcinoma, the IVW analysis produced odd ratios of 0.884, 95% confidence intervals of 0.747 to 1.045, and a p value of 0.148. In the case of small cell lung cancer, the odds ratio was 0.936, the 95% confidence interval was 0.751 to 1.166, and the p value was 0.554.

Conclusion

It can be concluded that there is no direct causal relationship between monounsaturated fatty acids and the development of lung cancer.

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查看原文本刊更多论文

单不饱和脂肪酸与肺癌之间的因果关系：一项双样本孟德尔随机研究。

目的：探讨单不饱和脂肪酸（MUFAs）与肺癌之间的潜在因果关系。方法：从全基因组关联研究（GWAS）中提取MUFAs与肺癌病理亚型的遗传数据。主要分析采用反方差加权分析（IVW），附加方法包括加权中位数法、MR-Egger回归法和加权模型法。进行敏感性分析以评估研究结果的稳健性。结果：单不饱和脂肪酸与肺腺癌相关的逆方差加权（IVW）分析得出优势比（OR）为1.059,95%置信区间为0.960 ~ 1.168，p值为0.252。同样，对于肺鳞状细胞癌，IVW分析的奇比为0.884,95%可信区间为0.747 ~ 1.045，p值为0.148。对于小细胞肺癌，比值比为0.936,95%可信区间为0.751 ~ 1.166，p值为0.554。结论：单不饱和脂肪酸与肺癌的发生无直接的因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Respiratory Journal 医学-呼吸系统

CiteScore

3.70

自引率

0.00%

发文量

104

审稿时长

>12 weeks

期刊介绍： Overview Effective with the 2016 volume, this journal will be published in an online-only format. Aims and Scope The Clinical Respiratory Journal (CRJ) provides a forum for clinical research in all areas of respiratory medicine from clinical lung disease to basic research relevant to the clinic. We publish original research, review articles, case studies, editorials and book reviews in all areas of clinical lung disease including: Asthma Allergy COPD Non-invasive ventilation Sleep related breathing disorders Interstitial lung diseases Lung cancer Clinical genetics Rhinitis Airway and lung infection Epidemiology Pediatrics CRJ provides a fast-track service for selected Phase II and Phase III trial studies. Keywords Clinical Respiratory Journal, respiratory, pulmonary, medicine, clinical, lung disease, Abstracting and Indexing Information Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Embase (Elsevier) Health & Medical Collection (ProQuest) Health Research Premium Collection (ProQuest) HEED: Health Economic Evaluations Database (Wiley-Blackwell) Hospital Premium Collection (ProQuest) Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) ProQuest Central (ProQuest) Science Citation Index Expanded (Clarivate Analytics) SCOPUS (Elsevier)