The mechanism and related research progress of GLP-1 receptor agonists in treating Alzheimer's disease.

Q3 Medicine

遗传 Pub Date : 2024-12-01 DOI:10.16288/j.yczz.24-178

Xiao-Cheng Zhu, Yi-Wen Wang, Hong-Wen Zhou

{"title":"The mechanism and related research progress of GLP-1 receptor agonists in treating Alzheimer's disease.","authors":"Xiao-Cheng Zhu, Yi-Wen Wang, Hong-Wen Zhou","doi":"10.16288/j.yczz.24-178","DOIUrl":null,"url":null,"abstract":"<p><p>GLP-1 receptor agonists are primarily used clinically for the treatment of type 2 diabetes and have the potential for weight loss, while they are currently expanding their horizons in the treatment of hypertension, non-alcoholic liver disease, depression, and neurodegenerative diseases. In particular, in the treatment of Alzheimer's disease, a large number of animal models and a handful of clinical studies have demonstrated the potential efficacy of GLP-1 receptor agonists, making it highly probable that they will become a new entrant in the drug list for Alzheimer's disease. At present, the research on the mechanism of GLP-1 receptor agonist in the treatment of Alzheimer's disease is mainly based on in-depth analysis of the pathogenesis of Alzheimer's disease and exploration of the mechanism of its comorbidity with diabetes. This article mainly reviews the latest advances in the mechanism of GLP-1 receptor agonists in the treatment of Alzheimer's disease, introduces the latest achievements in animal studies and clinical studies, and aims to provide reference for the subsequent relevant basic research and clinical application.</p>","PeriodicalId":35536,"journal":{"name":"遗传","volume":"46 12","pages":"1017-1027"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"遗传","FirstCategoryId":"1091","ListUrlMain":"https://doi.org/10.16288/j.yczz.24-178","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

GLP-1 receptor agonists are primarily used clinically for the treatment of type 2 diabetes and have the potential for weight loss, while they are currently expanding their horizons in the treatment of hypertension, non-alcoholic liver disease, depression, and neurodegenerative diseases. In particular, in the treatment of Alzheimer's disease, a large number of animal models and a handful of clinical studies have demonstrated the potential efficacy of GLP-1 receptor agonists, making it highly probable that they will become a new entrant in the drug list for Alzheimer's disease. At present, the research on the mechanism of GLP-1 receptor agonist in the treatment of Alzheimer's disease is mainly based on in-depth analysis of the pathogenesis of Alzheimer's disease and exploration of the mechanism of its comorbidity with diabetes. This article mainly reviews the latest advances in the mechanism of GLP-1 receptor agonists in the treatment of Alzheimer's disease, introduces the latest achievements in animal studies and clinical studies, and aims to provide reference for the subsequent relevant basic research and clinical application.

查看原文本刊更多论文

GLP-1受体激动剂治疗阿尔茨海默病的机制及相关研究进展。

GLP-1受体激动剂在临床上主要用于治疗2型糖尿病，具有减肥的潜力，目前正在扩大其在高血压、非酒精性肝病、抑郁症和神经退行性疾病的治疗领域。特别是在阿尔茨海默病的治疗方面，大量的动物模型和少量的临床研究已经证明了GLP-1受体激动剂的潜在疗效，使其极有可能成为阿尔茨海默病药物清单中的新进入者。目前对GLP-1受体激动剂治疗阿尔茨海默病机制的研究主要基于对阿尔茨海默病发病机制的深入分析和对其与糖尿病合并症机制的探索。本文主要综述GLP-1受体激动剂治疗阿尔茨海默病机制的最新进展，介绍动物研究和临床研究的最新成果，旨在为后续相关基础研究和临床应用提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

遗传 Medicine-Medicine (all)

CiteScore

2.50

自引率

0.00%

发文量

6699

期刊介绍： Hereditas is a national academic journal sponsored by the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and the Chinese Society of Genetics and published by Science Press. It is a Chinese core journal and a Chinese high-quality scientific journal. The journal mainly publishes innovative research papers in the fields of genetics, genomics, cell biology, developmental biology, biological evolution, genetic engineering and biotechnology; new technologies and new methods; monographs and reviews on hot issues in the discipline; academic debates and discussions; experience in genetics teaching; introductions to famous geneticists at home and abroad; genetic counseling; information on academic conferences at home and abroad, etc. Main columns: review, frontier focus, research report, technology and method, resources and platform, experimental operation guide, genetic resources, genetics teaching, scientific news, etc.