Association Between Maternal Prepregnancy and Pregnancy Body Mass Index and Children's Telomere Length: A Systematic Review and Meta-analysis.

IF 5.9 2区医学 Q1 NUTRITION & DIETETICS

Nutrition reviews Pub Date : 2024-12-10 DOI:10.1093/nutrit/nuae187

Amir Hossein Lame-Jouybari, Mohammad Salar Fahami, Mahla Sadat Hosseini, Maryam Moradpour, Ali Hojati, Mahdieh Abbasalizad-Farhangi

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引用次数: 0

Abstract

Context: Telomeres maintain chromosome stability and mark cellular aging, and their shortening with age compromises genomic stability.

Objective: The purpose of this study was to conduct a meta-analysis of existing evidence to evaluate the relationship between the maternal pregnancy body mass index (BMI) and children's telomere length (TL).

Data source: Web of Science, Scopus, and PubMed databases were systematically searched from their inception to August 27, 2023, for pertinent observational studies.

Data extraction: The random-effects meta-analysis was conducted on eligible studies that investigated the linear relationship between exposure and the outcomes of interest, utilizing the reported β-coefficient. Cochran's Q test and I2 statistics were used to assess heterogeneity.

Data analysis: A significant association was observed between maternal pregnancy BMI and children's TL (32 studies, pooled effect size [ES]: -0.04; 95% CI: -0.06 to -0.01; I2 = 47.51%, P < .001) and maternal prepregnancy BMI and children's TL at birth (16 studies; pooled ES: -0.05; 95% CI: -0.08 to -0.02; I2 = 53.49%, P < .001).

Conclusion: The findings indicate an inverse association between maternal prepregnancy BMI and TL in infants, which is evident within the normal to obese BMI range. This underscores the significance of maternal weight status before pregnancy as a determinant of offspring TL.

Systematic review registration: PROSPERO registration no. CRD42023466425.

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来源期刊

Nutrition reviews 医学-营养学

CiteScore

12.20

自引率

1.60%

发文量

121

审稿时长

6-12 weeks

期刊介绍： Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.