Silk Fibroin Hydrogels: Cutting-Edge Developments and Future Directions.

Q2 Pharmacology, Toxicology and Pharmaceutics

Pharmaceutical nanotechnology Pub Date : 2024-12-10 DOI:10.2174/0122117385339249241102165029

Govindaraj Sabarees, Ganesan Padmini Tamilarasi, Rajangam Jayaraman, Veerachamy Alagarsamy, Viswas Raja Solomon

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引用次数: 0

Abstract

The exploration of hydrogel materials has gained significant attention due to the ongoing period of collaborative interdisciplinary advancements. Silk fibroin (SF) possesses remarkable attributes, such as less immunogenicity, sterilization efficacy, processability without chemical crosslinkers, excellent biocompatibility, low immunogenicity, non-toxicity, mechanical strength, thermal stability, non-carcinogenicity, and adjustable biodegradability make it a highly valuable biomaterial. Silk fibroin hydrogel (SFH), a versatile biomaterial, has garnered significant attention due to its unique properties. Its biocompatibility, tunable mechanical properties, water retention capacity, and bioactive nature offer a unique combination of features that can effectively promote tissue regeneration and enhance wound healing. The utilization of SF for hydrogel production presents a valuable opportunity to leverage natural resources and promote eco-friendly production practices. With their exceptional properties and versatile applications in biomedicine, silk protein- based hydrogels hold promise for various research fields. This review aims to discuss the potential properties and recent advancements in the application of SF-based hydrogels for preclinical skin wound healing.

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丝素蛋白水凝胶：前沿发展和未来方向。

由于跨学科合作的持续发展，水凝胶材料的探索得到了极大的关注。丝素蛋白（Silk fibrin， SF）具有免疫原性低、杀菌效果好、无化学交联的加工性、优异的生物相容性、低免疫原性、无毒性、机械强度、热稳定性、非致癌性、可生物降解性可调等特点，是一种极具应用价值的生物材料。丝素水凝胶（SFH）是一种多用途的生物材料，因其独特的性能而备受关注。它的生物相容性、可调节的机械性能、保水能力和生物活性提供了独特的组合特征，可以有效地促进组织再生和促进伤口愈合。利用SF生产水凝胶提供了一个利用自然资源和促进环保生产实践的宝贵机会。丝蛋白基水凝胶以其独特的性能和在生物医学上的广泛应用，在许多研究领域有着广阔的前景。本文综述了sf基水凝胶在临床前皮肤创面愈合中的潜在性能和最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical nanotechnology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.20

自引率

0.00%

发文量

期刊介绍： Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.