Empowering Arthritis Patients: Optimized Drug Delivery through Piroxicam Microcapsule-Embedded Scaffold Implants via Box-Behnken Experimental Design.

Q2 Pharmacology, Toxicology and Pharmaceutics

Pharmaceutical nanotechnology Pub Date : 2024-12-10 DOI:10.2174/0122117385332757241104104727

Sampath Kumar, Mothilal Mohan

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引用次数: 0

Abstract

Background: The necessity for extended drug discharge to alleviate pain without adverse effects underscores the importance of innovative drug delivery systems. Achieving sustained pain relief without compromising patient safety is a critical objective in healthcare. By extending the duration of drug action while suppressing side effects, such systems offer enhanced therapeutic outcomes and improved patient quality of life.

Objective: This study endeavors to develop and appraise an innovative implantable drug delivery system by integrating NSAID-loaded gelatin microcapsules into a gelatin scaffold designed to augment drug delivery efficiency and sustain drug release.

Method: Piroxicam-loaded microcapsules with a 1:1 ratio of poly lactic acid and poly lacto glycolic acid showed smaller particle size, good yield, entrapment efficiency, and discharge. They were selected to make gelatin scaffolds with Box Behnken Design using Design Expert software for optimization. The better scaffolds were made in the form of rod-shaped sub-dermal implants. The primary focus of the investigation was the evaluation of critical parameters, specifically entrapment efficiency and drug discharge properties as dependent variables.

Results: Microcapsules with a 1:1 ratio of PLA and PLGA showed smaller particle sizes, good yield, entrapment efficiency, and discharge. Notably, the Design Expert-driven optimization yields highly favorable results. Furthermore, the scaffolds loaded with microcapsules exhibited favorable physicochemical assets, including drug discharge, for an extended period, underscoring their versatility for drug delivery.

Conclusion: By employing Design Expert software for optimization, the study demonstrates promising results, particularly in sustained pain management for arthritis, potentially improving therapeutic outcomes and patient quality of life. The study concludes that the prepared implants (holding scaffolds impregnated with piroxicam-loaded microcapsules) can be promising for relieving arthritis all day.

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增强关节炎患者的能力：通过Box-Behnken实验设计优化吡罗昔康微胶囊支架植入物的药物输送。

背景：延长药物释放以减轻疼痛而无不良反应的必要性强调了创新药物输送系统的重要性。在不损害患者安全的情况下实现持续的疼痛缓解是医疗保健的关键目标。通过延长药物作用的持续时间，同时抑制副作用，这种系统提供了增强的治疗结果和改善患者的生活质量。目的：通过将装载非甾体抗炎药（nsaid）的明胶微胶囊整合到明胶支架中，开发并评价一种创新的植入式给药系统，以提高给药效率并维持药物释放。方法：以聚乳酸与聚乳酸乙醇酸1:1的比例负载吡罗昔康微胶囊，粒径小，收率高，包封效率高，排药量大。他们被选中用Box Behnken Design使用Design Expert软件进行优化制作明胶支架。杆状皮下植入物是较好的支架。调查的主要重点是评估关键参数，特别是作为因变量的捕获效率和药物排放特性。结果：聚乳酸与聚乳酸比例为1:1的微胶囊具有粒径小、收率高、包封效率高、排药量大等特点。值得注意的是，设计专家驱动的优化产生了非常有利的结果。此外，负载微胶囊的支架在较长时间内表现出良好的物理化学资产，包括药物排出，强调了它们在药物输送方面的多功能性。结论：通过使用Design Expert软件进行优化，该研究显示了有希望的结果，特别是在关节炎的持续疼痛管理方面，有可能改善治疗结果和患者的生活质量。这项研究的结论是，这种制备好的植入物（用含有吡罗昔康的微胶囊浸没支架）有望全天缓解关节炎。

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来源期刊

Pharmaceutical nanotechnology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

4.20

自引率

0.00%

发文量

期刊介绍： Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.