Ali Zaheri Khosroshahi, Mohammad Ali Ghavimi, Simin Sharifi, Samin Baghban Vazirabadi, Tara Deljavanghodrati, Solmaz Maleki Dizaj
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引用次数: 0
Abstract
Introduction: A variety of hemostatic materials have been provided to accelerate the blood clotting process in dentistry. The purpose of this study was to investigate the biocompatibility and biodegradability of a hemostatic dental sponge containing aloe vera nanoparticles in rat animal models.
Methods and materials: Twelve adult Wistar rats in the weight range of 200 ± 30 grams and the same age range were randomly divided into two groups of test and control, and each group was divided into three subgroups of 3 days, 7 days, and 14 days. For implantation of the sponge, the animals were anesthetized with xylazine and ketamine, and a piece of the sponge was implanted under the skin at the cut site. In the control group of rats, only the skin was cut and sutured. After the specified number of days, the rats were anesthetized, and in addition to blood sampling, a tissue sample was taken from the animal's surgical site and fixed in 10% formalin. Then the samples were examined in macroscopic and microscopic conditions and finally, the obtained data were statistically analyzed.
Results: The results obtained in the present study indicated that the hemostat sponge had no side effects (biocompatible). In addition, it was completely absorbed during the 14 days of the study (biodegradable).
Conclusion: According to the characteristics of biocompatibility and biodegradability, the studied sponge can be used to control bleeding during dental surgeries or tooth extraction.
期刊介绍：
Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.
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