Effects of mindfulness-based stress reduction on neuropeptide Y plasma levels in stressed individuals

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-01-01 DOI:10.1016/j.jpsychires.2024.12.011

Helle Degnbol Østergaard , Karen Johanne Pallesen , Marit Nyholm Nielsen , Lone Fjorback , Lise Juul , Michael Winterdahl

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引用次数: 0

Abstract

Background

Clinical studies have suggested that dysregulation of the neuropeptide Y (NPY) system may play a role in psychiatric disorders, including chronic stress. Meanwhile, Mindfulness Based Stress Reduction (MBSR) has shown promise for stress-related maladies. However, no studies have explored whether MBSR can change plasma NPY concentration in stressed individuals.

Method

Individuals with symptoms of chronic stress were randomly assigned to eight weeks of either MBSR (n = 15), a locally-developed stress reduction intervention (LSR) (n = 15) or a wait-list control group (n = 20). Blood samples were collected at baseline and at a twelve-week follow-up to determine the effects of MBSR or LSR compared to the wait-list control group on NPY levels.

Results

The MBSR group had increased plasma NPY levels after the program compared to the waitlist control group, whereas the LSR group was not statistically different from the other groups.

Conclusion

This pilot study provides evidence of the feasibility of MBSR to alter plasma NPY.

查看原文本刊更多论文

正念减压对应激个体神经肽Y血浆水平的影响。

背景：临床研究表明神经肽Y （NPY）系统的失调可能在精神疾病中起作用，包括慢性应激。与此同时，正念减压法（MBSR）在治疗压力相关疾病方面显示出了希望。然而，没有研究探讨正念减压是否可以改变应激个体的血浆NPY浓度。方法：有慢性压力症状的个体被随机分配到8周的正念减压治疗组（n = 15）、局部减压干预组（n = 15）或等候名单对照组（n = 20）。在基线和12周的随访中收集血液样本，以确定MBSR或LSR与等候名单对照组相比对NPY水平的影响。结果：与等待名单对照组相比，MBSR组在计划后血浆NPY水平升高，而LSR组与其他组无统计学差异。结论：本初步研究为MBSR改变血浆NPY的可行性提供了证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;