Direct oral anticoagulants versus vitamin K antagonists in patients with thrombotic antiphospholipid syndrome: A prospective observational analysis.

IF 2.6 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Medicina Clinica Pub Date : 2024-12-09 DOI:10.1016/j.medcli.2024.10.020

Pablo Demelo-Rodríguez, Tatiana Pire-García, Sergio Moragón-Ledesma, Lucía Ordieres-Ortega, Francisco Galeano-Valle, Rubén Alonso-Beato

{"title":"Direct oral anticoagulants versus vitamin K antagonists in patients with thrombotic antiphospholipid syndrome: A prospective observational analysis.","authors":"Pablo Demelo-Rodríguez, Tatiana Pire-García, Sergio Moragón-Ledesma, Lucía Ordieres-Ortega, Francisco Galeano-Valle, Rubén Alonso-Beato","doi":"10.1016/j.medcli.2024.10.020","DOIUrl":null,"url":null,"abstract":"Background: The role of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) in the treatment of venous thromboembolism (VTE) in patients with antiphospholipid syndrome remains uncertain.Methods: We conducted a prospective observational study on APS patients with VTE treated with VKAs or DOACs in a tertiary hospital from 2010 to 2023. Clinical characteristics, recurrent arterial or VTE events, and hemorrhagic complications were analyzed over a one-year follow-up.Results: Fifty APS patients were included: 31 (62%) treated with VKAs and 19 (38%) with DOACs. Thrombotic recurrences occurred in 5 VKA patients (16.1%) and 3 DOAC patients (15.8%). Major bleeding occurred in 2 VKA patients (6.45%) and none in the DOAC group. There were no significant differences in thrombotic recurrence (OR 1.01; 95% CI: 0.19-5.46) or major bleeding (OR 1.09; 95% CI: 0.14-8.52) between groups.Conclusion: In APS patients with VTE, DOACs showed similar rates of recurrent thrombosis and major bleeding compared to VKAs. Future studies should therefore focus on the role of DOACs in APS patients with varying clinical and serological profiles.","PeriodicalId":18578,"journal":{"name":"Medicina Clinica","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicina Clinica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.medcli.2024.10.020","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The role of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) in the treatment of venous thromboembolism (VTE) in patients with antiphospholipid syndrome remains uncertain.

Methods: We conducted a prospective observational study on APS patients with VTE treated with VKAs or DOACs in a tertiary hospital from 2010 to 2023. Clinical characteristics, recurrent arterial or VTE events, and hemorrhagic complications were analyzed over a one-year follow-up.

Results: Fifty APS patients were included: 31 (62%) treated with VKAs and 19 (38%) with DOACs. Thrombotic recurrences occurred in 5 VKA patients (16.1%) and 3 DOAC patients (15.8%). Major bleeding occurred in 2 VKA patients (6.45%) and none in the DOAC group. There were no significant differences in thrombotic recurrence (OR 1.01; 95% CI: 0.19-5.46) or major bleeding (OR 1.09; 95% CI: 0.14-8.52) between groups.

Conclusion: In APS patients with VTE, DOACs showed similar rates of recurrent thrombosis and major bleeding compared to VKAs. Future studies should therefore focus on the role of DOACs in APS patients with varying clinical and serological profiles.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Medicina Clinica 医学-医学：内科

CiteScore

3.10

自引率

5.10%

发文量

295

审稿时长

22 days

期刊介绍： Medicina Clínica, fundada en 1943, es una publicación quincenal dedicada a la promoción de la investigación y de la práctica clínica entre los especialistas de la medicina interna, así como otras especialidades. Son características fundamentales de esta publicación el rigor científico y metodológico de sus artículos, la actualidad de los temas y, sobre todo, su sentido práctico, buscando siempre que la información sea de la mayor utilidad en la práctica clínica.