Causal association between sarcopenia and cognitive impairment contributes to the muscle–brain axis: A bidirectional Mendelian randomization study

IF 2.4 4区医学 Q3 GERIATRICS & GERONTOLOGY

Geriatrics & Gerontology International Pub Date : 2024-12-11 DOI:10.1111/ggi.15045

Lincheng Duan, Haoming Li, Shiyin Li, Yue Shi, Yue Feng

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引用次数: 0

Abstract

Aim

There is a growing body of evidence suggesting a correlation between sarcopenia (SP) and cognitive impairment (CI), but with conflict. This study employed a bidirectional Mendelian randomization (MR) approach to ascertain the causality between SP and CI.

Method

This study looked at whether there might be causality between SP and CI by using a bidirectional MR analysis on the GWAS summary datasets, which anyone can publicly access. The primary analysis employed inverse variance weighting (IVW), with MR-Egger, weighted median, and mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) serving as supplements. Multiple sensitivity analyses were performed to enhance the stability of the results, which encompassed heterogeneity tests and pleiotropy tests.

Results

Appendicular lean mass (ALM), walking pace (WP), and grip strength (GS) were found to be causally connected to cognitive performance in forward MR analysis. In the reverse MR study, cognitive performance also had a causal impact on ALM and WP. Additionally, we discovered comparable outcomes in the replication samples, which strengthens the validity of our findings.

Conclusions

The results of our MR investigation revealed a definitive cause-and-effect association between SP and CI. Our findings provide additional supporting evidence for the muscle–brain axis, which may suggest that muscle strengthening has a significant impact on the management and avoidance of CI. Geriatr Gerontol Int 2025; 25: 116–122.

查看原文本刊更多论文

肌肉减少症和认知障碍之间的因果关系有助于肌肉-脑轴：一项双向孟德尔随机研究。

目的：越来越多的证据表明肌肉减少症（SP）和认知障碍（CI）之间存在相关性，但两者之间存在冲突。本研究采用双向孟德尔随机化（MR）方法来确定SP和CI之间的因果关系。方法：本研究通过对任何人都可以公开访问的GWAS汇总数据集进行双向MR分析，研究SP和CI之间是否存在因果关系。主要分析采用逆方差加权法（IVW），以MR-Egger、加权中位数、孟德尔随机化多效残差和异常值（MR-PRESSO）作为补充。为了提高结果的稳定性，我们进行了多重敏感性分析，包括异质性试验和多效性试验。结果：在正向磁共振分析中发现阑尾瘦质量（ALM）、步行速度（WP）和握力（GS）与认知表现有因果关系。在反向MR研究中，认知表现对ALM和WP也有因果影响。此外，我们在复制样本中发现了可比较的结果，这加强了我们研究结果的有效性。结论：我们的MR调查结果揭示了SP和CI之间明确的因果关系。我们的研究结果为肌肉-脑轴提供了额外的支持证据，这可能表明肌肉强化对CI的管理和避免有重大影响。Geriatr Gerontol Int 2024；••: ••-••.

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Geriatrics & Gerontology International 医学-老年医学

CiteScore

5.50

自引率

6.10%

发文量

189

审稿时长

4-8 weeks

期刊介绍： Geriatrics & Gerontology International is the official Journal of the Japan Geriatrics Society, reflecting the growing importance of the subject area in developed economies and their particular significance to a country like Japan with a large aging population. Geriatrics & Gerontology International is now an international publication with contributions from around the world and published four times per year.