Impact of working memory training on brain network plasticity and genetic associations: insights from individual differences.

IF 2.9 2区 医学 Q2 NEUROSCIENCES
Hang Wu, Xiongying Chen, Yinlong Li, Wan Zhao, Bofan Zhang, Caiying Luo, Xinyue Zhang, Jing Shi, Qiumei Zhang, Gao Li, Jun Li
{"title":"Impact of working memory training on brain network plasticity and genetic associations: insights from individual differences.","authors":"Hang Wu, Xiongying Chen, Yinlong Li, Wan Zhao, Bofan Zhang, Caiying Luo, Xinyue Zhang, Jing Shi, Qiumei Zhang, Gao Li, Jun Li","doi":"10.1093/cercor/bhae445","DOIUrl":null,"url":null,"abstract":"<p><p>Considerable individual differences in learning ability have long been recognized, yet cognitive learning studies traditionally emphasized group averages while overlooking individual differences. We conducted intersubject similarity of functional connectivity analysis on a month-long randomized controlled trial dataset. Subjects in the training group, together with an additional 66 subjects undergoing the same training, were included to examine the correlations between intersubject similarity of functional connectivity and the intersubject similarity of single nucleotide polymorphisms related to mental disorders (schizophrenia, attention-deficient hyperactivity disorder, and autism spectrum disorder). We also used the Allen Human Brain Atlas to investigate genetic correlations at the gene expression level. Training increased the intersubject similarity of functional connectivity of some brain networks (especially the limbic network-frontoparietal network) across the resting and task states. Furthermore, the change in the intersubject similarity of functional connectivity of the limbic network-frontoparietal network after training seems to have a different genetic basis from its intersubject similarity of functional connectivity at baseline. Allen Human Brain Atlas analysis on the limbic network-frontoparietal network indicated correlations at baseline functional connectivity weights functional connectivity. Working memory training resulted in specific brain changes that differed among individuals, which may be partially due to genetics, especially concerning single nucleotide polymorphisms related to schizophrenia. Our findings emphasize the need to consider individual genetic backgrounds in personalized cognitive training.</p>","PeriodicalId":9715,"journal":{"name":"Cerebral cortex","volume":"34 12","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cerebral cortex","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/cercor/bhae445","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Considerable individual differences in learning ability have long been recognized, yet cognitive learning studies traditionally emphasized group averages while overlooking individual differences. We conducted intersubject similarity of functional connectivity analysis on a month-long randomized controlled trial dataset. Subjects in the training group, together with an additional 66 subjects undergoing the same training, were included to examine the correlations between intersubject similarity of functional connectivity and the intersubject similarity of single nucleotide polymorphisms related to mental disorders (schizophrenia, attention-deficient hyperactivity disorder, and autism spectrum disorder). We also used the Allen Human Brain Atlas to investigate genetic correlations at the gene expression level. Training increased the intersubject similarity of functional connectivity of some brain networks (especially the limbic network-frontoparietal network) across the resting and task states. Furthermore, the change in the intersubject similarity of functional connectivity of the limbic network-frontoparietal network after training seems to have a different genetic basis from its intersubject similarity of functional connectivity at baseline. Allen Human Brain Atlas analysis on the limbic network-frontoparietal network indicated correlations at baseline functional connectivity weights functional connectivity. Working memory training resulted in specific brain changes that differed among individuals, which may be partially due to genetics, especially concerning single nucleotide polymorphisms related to schizophrenia. Our findings emphasize the need to consider individual genetic backgrounds in personalized cognitive training.

工作记忆训练对大脑网络可塑性和遗传关联的影响:来自个体差异的见解。
人们早就认识到学习能力的巨大个体差异,但认知学习研究传统上强调群体平均而忽视个体差异。我们对一个为期一个月的随机对照试验数据集进行了功能连接的主体间相似性分析。训练组的受试者,以及另外66名接受相同训练的受试者,被纳入研究功能连接的主体间相似性和与精神障碍(精神分裂症、注意力缺陷多动障碍和自闭症谱系障碍)相关的单核苷酸多态性的主体间相似性之间的相关性。我们还使用Allen人脑图谱来研究基因表达水平上的遗传相关性。在静息状态和任务状态下,训练增加了某些脑网络(尤其是边缘网络-额顶叶网络)功能连通性的主体间相似性。此外,训练后大脑边缘网络-额顶叶网络功能连接的主体间相似性变化与其基线时的主体间功能连接相似度似乎具有不同的遗传基础。Allen人脑图谱对边缘网络-额顶叶网络的分析表明,在基线功能连通性权重上存在相关性。工作记忆训练导致不同个体的特定大脑变化,这可能部分是由于遗传,特别是与精神分裂症相关的单核苷酸多态性。我们的发现强调了在个性化认知训练中考虑个体遗传背景的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Cerebral cortex
Cerebral cortex 医学-神经科学
CiteScore
6.30
自引率
8.10%
发文量
510
审稿时长
2 months
期刊介绍: Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信