The study on agitation and structure of orbitofrontal cortex subregion in first-episode drug-naïve patients with schizophrenia.

IF 2.4 3区 医学 Q2 NEUROIMAGING
Brain Imaging and Behavior Pub Date : 2025-02-01 Epub Date: 2024-12-11 DOI:10.1007/s11682-024-00961-z
Yingbo Dong, Congxin Chen, Yuting Li, Peiyu Cao, Yilin Tang, Guoxin Xu, Qi Si, Runda Li, Yuxiu Sui
{"title":"The study on agitation and structure of orbitofrontal cortex subregion in first-episode drug-naïve patients with schizophrenia.","authors":"Yingbo Dong, Congxin Chen, Yuting Li, Peiyu Cao, Yilin Tang, Guoxin Xu, Qi Si, Runda Li, Yuxiu Sui","doi":"10.1007/s11682-024-00961-z","DOIUrl":null,"url":null,"abstract":"<p><p>Agitation is one of the core symptoms of schizophrenia. The occurrence of agitation may be related to orbitofrontal cortex dysfunction. However, due to methodological heterogeneity, the relationship between agitation and orbitofrontal cortex subregions remains unclear. Based on the multi-dimensional structure of the orbitofrontal cortex subregion, this study aims to explore the relationship between orbitofrontal cortex structure and agitation in first-episode drug-naïve patients with schizophrenia. The study subjects included 50 first-episode drug-naïve patients with schizophrenia and 29 healthy controls. All participants underwent structure magnetic resonance imaging scanning. The patients' clinical symptoms were assessed using the Positive and Negative Syndrome Scale, and the agitation were evaluated using the Brief Agitation Rating Scale. SPSS 26.0 was used to compare the differences in the orbitofrontal cortex subregion between the two groups in different structure dimensions and then conduct a Pearson's partial correlations analysis to observe the relationship between orbitofrontal cortex subregion structure and agitation. There were no significant differences in demographic factors between the two groups. Our results show the folding index of the orbitofrontal cortex subregion in patients with schizophrenia were significantly smaller compared to the healthy controls. The surface area in the orbitofrontal cortex subregion is significantly negatively correlated with agitation in first-episode drug-naïve schizophrenia patients. These results suggest that structure alterations in the orbitofrontal cortex subregion may be involved in schizophrenia agitation.</p>","PeriodicalId":9192,"journal":{"name":"Brain Imaging and Behavior","volume":" ","pages":"175-188"},"PeriodicalIF":2.4000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Imaging and Behavior","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11682-024-00961-z","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/11 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"NEUROIMAGING","Score":null,"Total":0}
引用次数: 0

Abstract

Agitation is one of the core symptoms of schizophrenia. The occurrence of agitation may be related to orbitofrontal cortex dysfunction. However, due to methodological heterogeneity, the relationship between agitation and orbitofrontal cortex subregions remains unclear. Based on the multi-dimensional structure of the orbitofrontal cortex subregion, this study aims to explore the relationship between orbitofrontal cortex structure and agitation in first-episode drug-naïve patients with schizophrenia. The study subjects included 50 first-episode drug-naïve patients with schizophrenia and 29 healthy controls. All participants underwent structure magnetic resonance imaging scanning. The patients' clinical symptoms were assessed using the Positive and Negative Syndrome Scale, and the agitation were evaluated using the Brief Agitation Rating Scale. SPSS 26.0 was used to compare the differences in the orbitofrontal cortex subregion between the two groups in different structure dimensions and then conduct a Pearson's partial correlations analysis to observe the relationship between orbitofrontal cortex subregion structure and agitation. There were no significant differences in demographic factors between the two groups. Our results show the folding index of the orbitofrontal cortex subregion in patients with schizophrenia were significantly smaller compared to the healthy controls. The surface area in the orbitofrontal cortex subregion is significantly negatively correlated with agitation in first-episode drug-naïve schizophrenia patients. These results suggest that structure alterations in the orbitofrontal cortex subregion may be involved in schizophrenia agitation.

首发drug-naïve精神分裂症患者的躁动及眶额叶皮层亚区结构研究。
躁动是精神分裂症的核心症状之一。躁动的发生可能与眶额皮质功能障碍有关。然而,由于方法的异质性,躁动和眶额叶皮层亚区之间的关系尚不清楚。本研究旨在通过眼眶额叶皮层亚区的多维结构,探讨首发drug-naïve精神分裂症患者眼眶额叶皮层结构与躁动的关系。研究对象包括50名首发drug-naïve精神分裂症患者和29名健康对照者。所有参与者都进行了结构磁共振成像扫描。采用阳性与阴性综合征量表评定患者临床症状,采用简易躁动评定量表评定患者躁动程度。采用SPSS 26.0软件比较两组在不同结构维度下眶额皮质亚区差异,并进行Pearson偏相关分析,观察眶额皮质亚区结构与躁动的关系。两组间人口统计学因素无显著差异。我们的研究结果表明,精神分裂症患者的眶额皮质亚区折叠指数明显小于健康对照组。首发drug-naïve精神分裂症患者眼窝额叶皮层亚区表面积与躁动呈显著负相关。这些结果表明,眶额叶皮层亚区结构的改变可能与精神分裂症躁动有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Brain Imaging and Behavior
Brain Imaging and Behavior 医学-神经成像
CiteScore
7.20
自引率
0.00%
发文量
154
审稿时长
3 months
期刊介绍: Brain Imaging and Behavior is a bi-monthly, peer-reviewed journal, that publishes clinically relevant research using neuroimaging approaches to enhance our understanding of disorders of higher brain function. The journal is targeted at clinicians and researchers in fields concerned with human brain-behavior relationships, such as neuropsychology, psychiatry, neurology, neurosurgery, rehabilitation, and cognitive neuroscience.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信